Kinetics of Enzyme Inhibition by Active Molluscicidal Agents Ferulic Acid, Umbelliferone, Eugenol and Limonene in the Nervous Tissue of Snail Lymnaea acuminata

被引：40

作者：

Kumar, Pradeep ^{[1
]}

Singh, V. K. ^{[1
]}

Singh, D. K. ^{[1
]}

机构：

[1] DDU Gorakhpur Univ, Dept Zool, Malacol Lab, Gorakhpur 273009, Uttar Pradesh, India

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 02期

关键词：

ferulic acid; umbelliferone; eugenol; limonene; Lymnaea acuminata; PLANT-DERIVED MOLLUSCICIDES; SYNERGISM; BINARY; SINGLE;

D O I：

10.1002/ptr.2578

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ferulic acid, umbelliferone (Ferula asafoetida), eugenol (Syzygium aromaticum) and limonene (Carum carvi) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata. It was observed that ferulic acid, umbelliferone and eugenol are competitive and limonene is a competitive-non-competitive inhibitor of alkaline phosphatase. Ferulic acid and umbelliferone are competitive, whereas eugenol and limonene are competitive-non-competitive and uncompetitive inhibitors of acetylcholinesterase, respectively. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：172 / 177

页数：6

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