Lipase-catalyzed Synthesis of Caffeic Acid Propyl Ester in Ionic Liquid

被引：3

作者：

Pang, Na ^{[1
]}

Wang, Fangqin ^{[1
]}

Cui, Hongsheng ^{[1
]}

Zhao, Xingyu ^{[1
]}

Liu, Xi ^{[1
]}

Gu, Shuangshuang ^{[1
]}

Wang, Jun ^{[1
]}

机构：

[1] Jiangsu Univ Sci & Technol, Sch Biol & Chem Engn, Zhenjiang 212018, Peoples R China

来源：

ADVANCES IN CHEMICAL, MATERIAL AND METALLURGICAL ENGINEERING, PTS 1-5 | 2013年 / 634-638卷

关键词：

Biosynthesis; Caffeic acid propyl ester; Lipase; Ionic liquid; Esterification; ENZYMATIC-SYNTHESIS; PHENETHYL ESTER; ALKYL ESTERS;

D O I：

10.4028/www.scientific.net/AMR.634-638.555

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Lipase-catalyzed esterification of caffeic acid with 1-propanol, to form caffeic acid propyl ester (CAPE), was investigated in ionic liquid using immobilized lipase. Ten ILs were used as the reaction medium; three types of lipases were selected as biocatalysts, and the lipase-catalyzed synthesis properties of CAPE were measured systematically in order to enhance the yield of CAPE. The results indicated that when [Bmim][Tf2N] was selected as reaction media, Novozym 435 was used as catalyst, the molar ratio of 1-propanol to CA was 10:1, the reaction temperature was 80 degrees C, and the mass ratio of catalyst to CA was 18:1, the highst yield of CAPE attained 41.0 %.

引用

页码：555 / 558

页数：4

共 11 条

[1] Biocatalytic preparation of alkyl esters of citrus flavanone glucoside prunin in organic media [J].

Celiz, Gustavo ;

Daz, Mirta .

PROCESS BIOCHEMISTRY, 2011, 46 (01) :94-100

[2] Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress [J].

Garrido, Jorge ;

Gaspar, Alexandra ;

Manuela Garrido, E. ;

Miri, Ramin ;

Tavakkoli, Marjan ;

Pourali, Samaneh ;

Saso, Luciano ;

Borges, Fernanda ;

Firuzi, Omidreza .

BIOCHIMIE, 2012, 94 (04) :961-967

[3] Synthesis of ethyl ferulate in organic medium using celite-immobilized lipase [J].

Kumar, Ashok ;

Kanwar, Shamsher S. .

BIORESOURCE TECHNOLOGY, 2011, 102 (03) :2162-2167

[4] Enzymatic synthesis of caffeic acid phenethyl ester analogues in ionic liquid [J].

Kurata, Atsushi ;

Kitamura, Yuki ;

Irie, Shiori ;

Takemoto, Shintaro ;

Akai, Yoshiaki ;

Hirota, Yoshitaka ;

Fujita, Tokio ;

Iwai, Kazuya ;

Furusawa, Mina ;

Kishimoto, Noriaki .

JOURNAL OF BIOTECHNOLOGY, 2010, 148 (2-3) :133-138

[5] Esterification of different acids over heterogeneous and homogeneous catalysts and correlation with the Taft equation [J].

Lilja, J ;

Murzin, DY ;

Salmi, T ;

Aumo, J ;

Arvela, PM ;

Sundell, M .

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2002, 182 (01) :555-563

[6] EFFECT OF CAFFEIC ACID-ESTERS ON CARCINOGEN-INDUCED MUTAGENICITY AND HUMAN COLON ADENOCARCINOMA CELL-GROWTH [J].

RAO, CV ;

DESAI, D ;

KAUL, BP ;

AMIN, S ;

REDDY, BS .

CHEMICO-BIOLOGICAL INTERACTIONS, 1992, 84 (03) :277-290

[7] Studies on the enzymatic synthesis of lipophilic derivatives of natural antioxidants [J].

Stamatis, H ;

Sereti, V ;

Kolisis, FN .

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1999, 76 (12) :1505-1510

[8] Biocatalytic transformations in ionic liquids [J].

van Rantwijk, F ;

Lau, RM ;

Sheldon, RA .

TRENDS IN BIOTECHNOLOGY, 2003, 21 (03) :131-138

[9] Selective hydrolysis by commercially available hesperidinase for isoquercitrin production [J].

Wang, Jun ;

Ma, Yan-Long ;

Wu, Xiang-Yang ;

Yu, Liang ;

Xia, Rui ;

Sun, Guo-Xia ;

Wu, Fu-An .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2012, 81 :37-42

[10] Pentyl (E)-3-(3,4-dihydroxyphenyl)acrylate [J].

Wang, Jun ;

Gu, Shuangshuang ;

Zhang, Leixia ;

Wu, Fuan ;

Guo, Xijie .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 :O2871-+

← 1 2 →