The Immune Response in Tuberculosis

被引：941

作者：

O'Garra, Anne ^{[1
,3
]}

Redford, Paul S. ^{[1
]}

McNab, Finlay W. ^{[1
]}

Bloom, Chloe I. ^{[1
]}

Wilkinson, Robert J. ^{[1
,2
,3
,4
]}

Berry, Matthew P. R. ^{[1
,5
]}

机构：

[1] Natl Inst Med Res, MRC, Div Immunoregulat, London NW7 1AA, England

[2] Natl Inst Med Res, MRC, Div Mycobacterial Res, London NW7 1AA, England

[3] Univ London Imperial Coll Sci Technol & Med, Div Med, London W2 1PG, England

[4] Univ Cape Town, Inst Infect Dis & Mol Med, Clin Dis Res Initiat, Fac Hlth Sci, ZA-7925 Cape Town, South Africa

[5] Imperial Coll Healthcare NHS Trust, St Marys Hosp, London W2 1NY, England

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 | 2013年 / 31卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

M; tuberculosis; infection; cytokines; protection; pathogenesis; T-CELL RESPONSES; RECONSTITUTION INFLAMMATORY SYNDROME; ACTIVE PULMONARY TUBERCULOSIS; HUMAN-IMMUNODEFICIENCY-VIRUS; CALMETTE-GUERIN VACCINATION; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; HIV-INFECTED PATIENTS; MYCOBACTERIUM-TUBERCULOSIS; INTERFERON-GAMMA;

D O I：

10.1146/annurev-immunol-032712-095939

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There are 9 million cases of active tuberculosis reported annually; however, an estimated one-third of the world's population is infected with Mycobacterium tuberculosis and remains asymptomatic. Of these latent individuals, only 5-10% will develop active tuberculosis disease in their lifetime. CD4(+) T cells, as well as the cytokines IL-12, IFN-gamma, and TNF, are critical in the control of Mycobacterium tuberculosis infection, but the host factors that determine why some individuals are protected from infection while others go on to develop disease are unclear. Genetic factors of the host and of the pathogen itself may be associated with an increased risk of patients developing active tuberculosis. This review aims to summarize what we know about the immune response in tuberculosis, in human disease, and in a range of experimental models, all of which are essential to advancing our mechanistic knowledge base of the host-pathogen interactions that influence disease outcome.

引用

页码：475 / 527

页数：53

共 362 条

[1] Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes [J].