Ionic liquid promoted simple and efficient synthesis of β-enamino esters and β-enaminones from 1,3-dicarbonyl compounds -: One-pot, three-component reaction for the synthesis of substituted pyridines

被引：35

作者：

Karthikeyan, G ^{[1
]}

Perumal, PT ^{[1
]}

机构：

[1] Cent Leather Res Inst, Dept Organ Chem, Madras 600020, Tamil Nadu, India

来源：

CANADIAN JOURNAL OF CHEMISTRY | 2005年 / 83卷 / 10期

关键词：

ionic liquid; beta-enaminones; beta-enamino esters; 1,3-dicarbonyl compounds; amines; pyridines;

D O I：

10.1139/V05-186

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile enamination of 1,3-dicarbonyl compounds with amines has been developed that affords good to excellent yields of beta-enamino esters and beta-enaminones using Bronsted acidic ionic liquid 1-methylimidazolium trifluoroacetate ([Hmim](+)Tfa(-)) at room temperature. This methodology has been extended for the synthesis of substituted pyridines in excellent yield by a one-pot, three-component reaction of 1,3-dicarbonyl compounds, ammonium acetate, and alkynone in the presence of [Hmim](+)Tfa(-).

引用

页码：1746 / 1751

页数：6

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