Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis

被引：87
作者：
Bellavia, D. [1 ,5 ]
De Luca, A. [1 ,5 ]
Carina, V [1 ,5 ]
Costa, V [1 ,5 ]
Raimondi, L. [1 ,5 ]
Salamanna, F. [2 ]
Alessandro, R. [3 ,4 ]
Fini, M. [2 ]
Giavaresi, G. [2 ]
机构：
[1] IRCCS Ist Ortoped Rizzoli, Bologna, Italy
[2] IRCCS Ist Ortoped Rizzoli, Lab Preclin & Surg Studies, Bologna, Italy
[3] Univ Palermo, Dept Biopathol & Med Biotechnol, Sect Biol & Genet, I-90133 Palermo, Italy
[4] CNR, Inst Biomed & Mol Immunol IBIM, Palermo, Italy
[5] IRCCS Ist Ortoped Rizzoli, Technol Platforms Tissue Engn Theranost & Oncol, Via Divisi 83, I-90133 Palermo, Italy
来源：
BONE | 2019年 / 122卷
关键词：
miRNA; Osteoporosis; Osteogenesis; Osteoblast; Osteoclast; MESENCHYMAL STEM-CELLS; PROMOTES OSTEOBLAST DIFFERENTIATION; INHIBITED OSTEOGENIC DIFFERENTIATION; REGULATES OSTEOCLAST DIFFERENTIATION; POSTMENOPAUSAL OSTEOPOROSIS; MICRORNA EXPRESSION; ADIPOGENIC DIFFERENTIATION; LINEAGE PROGRESSION; CIRCULATING MIRNAS; TARGETING RUNX2;
D O I：
10.1016/j.bone.2019.02.013
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. The present review intends to give an exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development. Moreover, the review analyzes miRNAs identified in clinical trials and involved in osteoporosis.
引用
收藏
页码：52 / 75
页数：24
相关论文
共 187 条
[11]   Effects of endogenous hypercortisolism on bone mRNA and microRNA expression in humans [J].
Belaya, Z. E. ;
Grebennikova, T. A. ;
Melnichenko, G. A. ;
Nikitin, A. G. ;
Solodovnikov, A. G. ;
Brovkina, O. I. ;
Grigoriev, A. U. ;
Rozhinskaya, L. Y. ;
Dedov, I. I. .
OSTEOPOROSIS INTERNATIONAL, 2018, 29 (01) :211-221
[12]   miR-181a promotes osteoblastic differentiation through repression of TGF-β signaling molecules [J].
Bhushan, Raghu ;
Gruenhagen, Johannes ;
Becker, Jessica ;
Robinson, Peter N. ;
Ott, Claus-Eric ;
Knaus, Petra .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2013, 45 (03) :696-705
[13]   microRNA-124 inhibits bone metastasis of breast cancer by repressing Interleukin-11 [J].
Cai, Wei-Luo ;
Huang, Wen-Ding ;
Li, Bo ;
Chen, Tian-Rui ;
Li, Zhen-Xi ;
Zhao, Cheng-Long ;
Li, Heng-Yu ;
Wu, Yan-Mei ;
Yan, Wang-Jun ;
Xiao, Jian-Ru .
MOLECULAR CANCER, 2018, 17
[14]   MicroRNA-153 suppresses the osteogenic differentiation of human mesenchymal stem cells by targeting bone morphogenetic protein receptor type II [J].
Cao, Yujing ;
Lv, Qiuxia ;
Lv, Cuitian .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2015, 36 (03) :760-766
[15]   MiR-422a as a Potential Cellular MicroRNA Biomarker for Postmenopausal Osteoporosis [J].
Cao, Zheng ;
Moore, Benjamin T. ;
Wang, Yang ;
Peng, Xian-Hao ;
Lappe, Joan M. ;
Recker, Robert R. ;
Xiao, Peng .
PLOS ONE, 2014, 9 (05)
[16]   Harnessing a Novel Inhibitory Role of miR-16 in Osteogenesis by Human Mesenchymal Stem Cells for Advanced Scaffold-Based Bone Tissue Engineering [J].
Castano, Irene Mencia ;
Curtin, Caroline M. ;
Duffy, Garry P. ;
O'Brien, Fergal J. .
TISSUE ENGINEERING PART A, 2019, 25 (1-2) :24-33
[17]   MiR-503 Regulates Osteoclastogenesis via Targeting RANK [J].
Chen, Chao ;
Cheng, Peng ;
Xie, Hui ;
Zhou, Hou-De ;
Wu, Xian-Ping ;
Liao, Er-Yuan ;
Luo, Xiang-Hang .
JOURNAL OF BONE AND MINERAL RESEARCH, 2014, 29 (02) :338-347
[18]   miR-628-3p regulates osteoblast differentiation by targeting RUNX2: Possible role in atrophic non-union [J].
Chen, Hua ;
Ji, Xinran ;
She, Fei ;
Gao, Yuan ;
Tang, Peifu .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 39 (02) :279-286
[19]   Identification of suitable reference gene and biomarkers of serum miRNAs for osteoporosis [J].
Chen, Jian ;
Li, Kai ;
Pang, Qianqian ;
Yang, Chao ;
Zhang, Hongyu ;
Wu, Feng ;
Cao, Hongqing ;
Liu, Hongju ;
Wan, Yumin ;
Xia, Weibo ;
Wang, Jinfu ;
Dai, Zhongquan ;
Li, Yinghui .
SCIENTIFIC REPORTS, 2016, 6
[20]   miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis [J].
Chen, Ke ;
He, Honghui ;
Xie, Yanhong ;
Zhao, Liling ;
Zhao, Shaoli ;
Wan, Xinxing ;
Yang, Wenjun ;
Mo, Zhaohui .
SCIENTIFIC REPORTS, 2015, 5
12345678910