Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis

被引：87

作者：

Bellavia, D. ^{[1
,5
]}

De Luca, A. ^{[1
,5
]}

Carina, V ^{[1
,5
]}

Costa, V ^{[1
,5
]}

Raimondi, L. ^{[1
,5
]}

Salamanna, F. ^{[2
]}

Alessandro, R. ^{[3
,4
]}

Fini, M. ^{[2
]}

Giavaresi, G. ^{[2
]}

机构：

[1] IRCCS Ist Ortoped Rizzoli, Bologna, Italy

[2] IRCCS Ist Ortoped Rizzoli, Lab Preclin & Surg Studies, Bologna, Italy

[3] Univ Palermo, Dept Biopathol & Med Biotechnol, Sect Biol & Genet, I-90133 Palermo, Italy

[4] CNR, Inst Biomed & Mol Immunol IBIM, Palermo, Italy

[5] IRCCS Ist Ortoped Rizzoli, Technol Platforms Tissue Engn Theranost & Oncol, Via Divisi 83, I-90133 Palermo, Italy

来源：

BONE | 2019年 / 122卷

关键词：

miRNA; Osteoporosis; Osteogenesis; Osteoblast; Osteoclast; MESENCHYMAL STEM-CELLS; PROMOTES OSTEOBLAST DIFFERENTIATION; INHIBITED OSTEOGENIC DIFFERENTIATION; REGULATES OSTEOCLAST DIFFERENTIATION; POSTMENOPAUSAL OSTEOPOROSIS; MICRORNA EXPRESSION; ADIPOGENIC DIFFERENTIATION; LINEAGE PROGRESSION; CIRCULATING MIRNAS; TARGETING RUNX2;

D O I：

10.1016/j.bone.2019.02.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. The present review intends to give an exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development. Moreover, the review analyzes miRNAs identified in clinical trials and involved in osteoporosis.

引用

页码：52 / 75

页数：24

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