A review of Omics research in acupuncture: The relevance and future prospects for understanding the nature of meridians and acupoints

被引:36
作者
Jia, Jun [2 ]
Yu, Yan [2 ]
Deng, Jia-Hui [2 ]
Robinson, Nicola [3 ]
Bovey, Mark [4 ]
Cui, Yun-Hua [5 ]
Liu, Hui-Rong [5 ]
Ding, Wei [1 ]
Wu, Huan-Gan [5 ]
Wang, Xiao-Min [2 ]
机构
[1] Capital Med Univ, Dept Biochem & Mol Biol, Beijing 100069, Peoples R China
[2] Capital Med Univ, Dept Physiol, Beijing 100069, Peoples R China
[3] London S Bank Univ, Fac Hlth & Social Care, London SE1 0AA, England
[4] British Acupuncture Council, London W12 9HQ, England
[5] Shanghai Inst Acupuncture Moxibust & Meridians, Shanghai 200030, Peoples R China
基金
中国国家自然科学基金;
关键词
Acupuncture-moxibustion; Meridian system; Acupoints; Omics; Systems biology; GENE-EXPRESSION PROFILE; AGING-RELATED CHANGES; PROTEOMIC ANALYSIS; MICROARRAY ANALYSIS; NEUROPATHIC PAIN; MESSENGER-RNA; ELECTROACUPUNCTURE; STIMULATION; MEDICINE; BRAIN;
D O I
10.1016/j.jep.2012.01.034
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Relevance: Acupuncture is an intrinsic part of traditional Chinese medicine. The current understanding of the acupuncture meridian system, acupoints and the potential utilizing Omics technologies are summarized in this review. Material and methods: A systematic search for acupuncture involving Omics technologies was carried out using multiple online literature databases. The records retrieved were from the full collections of each database dated to September 2011. Data produced from functional genomic technologies were extracted from the collected acupuncture/moxibustion studies and subjected to evaluation. Analyses and comments were summarized on the advances in experimental research in acupuncture/moxibustion-related studies, and the future for strategies and approaches in the era of functional genomics highlighted. Results: An overview of articles indicated that several diseases or symptoms with evidence of effectiveness had been piloted for using functional genomic technologies, such as Parkinson's disease, allergic disorders, pain, and spinal cord injury, most of which are chronic "difficult diseases". High-throughput genomic and proteomic profiling of gene expression in tissues has been able to identify potential candidates for the effects of acupuncture and provide valuable information toward understanding the possible mechanisms of the therapy. However, without further holistic and sophisticated analyses in the context of metabolomics and systems biology, the current attempts and the foreseeable developments appear to be insufficient to produce firm conclusions. Noticeably, the recent rapid advances in functional molecular imaging targeting specific metabolites have shown great promise and if combined with other post-genomic technologies, could be extremely helpful for the acupuncture studies in human subjects. Conclusion: This review suggest that disease-oriented studies using the approach of multi-indexed high-throughput technologies and systems biology analyses will be a preferred strategy for future acupuncture/moxibustion research. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:594 / 603
页数:10
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