Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges

被引:164
作者
Bron, Johannes Leendert [2 ,3 ]
Helder, Marco N. [2 ,3 ]
Meisel, Hans-Jorg [2 ,4 ]
Royen, Barend J. Van [2 ,3 ]
Smit, Theodoor H. [1 ,3 ]
机构
[1] Vrije Univ Amsterdam, Dept Phys & Med Technol, Med Ctr, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Dept Orthopaed Surg, Med Ctr, NL-1007 MB Amsterdam, Netherlands
[3] Skeletal Tissue Engn Grp Amsterdam STEGA Fdn, Res Inst MOVE, Amsterdam, Netherlands
[4] BG Clin Bergmannstrost, Dept Neurosurg, Halle, Germany
关键词
Annulus fibrosus; Herniation; Discectomy; Repair; Regeneration; LUMBAR DISC HERNIATION; HUMAN INTERVERTEBRAL DISC; NUCLEUS PULPOSUS CELLS; LONG-TERM OUTCOMES; ANULUS FIBROSUS; EXTRACELLULAR-MATRIX; ELASTIC FIBERS; IN-VITRO; CHONDROCYTE TRANSPLANTATION; NONSURGICAL MANAGEMENT;
D O I
10.1007/s00586-008-0856-x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Lumbar discectomy is a very effective therapy for neurological decompression in patients suffering from sciatica due to hernia nuclei pulposus. However, high recurrence rates and persisting post-operative low back pain in these patients require serious attention. In the past decade, tissue engineering strategies have been developed mainly targeted to the regeneration of the nucleus pulposus (NP) of the intervertebral disc. Accompanying techniques that deal with the damaged annulus fibrous are now increasingly recognised as mandatory in order to prevent re-herniation to increase the potential of NP repair and to confine NP replacement therapies. In the current review, the requirements, achievements and challenges in this quickly emerging field of research are discussed.
引用
收藏
页码:301 / 313
页数:13
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