Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy

被引：214
作者：
Guo, Xing [1 ]
Wei, Xiao [1 ]
Jing, Yuting [2 ]
Zhou, Shaobing [1 ,2 ]
机构：
[1] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China
[2] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 41期
基金：
中国国家自然科学基金;
关键词：
DRUG-DELIVERY; IN-VIVO; BREAST-CANCER; CO-DELIVERY; NANOPARTICLES; DOXORUBICIN; CELLS; PENETRATION; MICELLES; THERAPEUTICS;
D O I：
10.1002/adma.201502865
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A size changeable polymer micelle system with a dual shell, which increases in size under acidic pH conditions and is altered to smaller micelles, triggered by intracellular glutathione (GSH), is successfully developed. It is capable of direct delivering anticancer drugs to the nucleus of multidrug resistance (MDR) tumor cells for highly effective combating of drug resistant breast cancer.
引用
收藏
页码：6450 / +
页数：8
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