MxB is an interferon-induced restriction factor of human herpesviruses

被引：100

作者：

Crameri, Michel ^{[1
,2
]}

Bauer, Michael ^{[2
,3
]}

Caduff, Nicole ^{[2
,4
]}

Walker, Raphael ^{[1
]}

Steiner, Fiona ^{[1
,2
]}

Franzoso, Francesca D. ^{[5
,6
]}

Gujer, Cornelia ^{[4
]}

Boucke, Karin ^{[3
]}

Kucera, Talissa ^{[1
]}

Zbinden, Andrea ^{[1
]}

Muenz, Christian ^{[4
]}

Fraefel, Cornel ^{[5
]}

Greber, Urs F. ^{[3
]}

Pavlovic, Jovan ^{[1
]}

机构：

[1] Univ Zurich, Inst Med Virol, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[2] Life Sci Zurich Grad Sch, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[3] Univ Zurich, Inst Mol Life Sci, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[4] Univ Zurich, Inst Expt Immunol, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[5] Univ Zurich, Inst Virol, Winterthurerstr 266a, CH-8057 Zurich, Switzerland

[6] Univ Hosp Zurich, Dept Neurosurg & Neuropathol, Frauenklinikstr 10, CH-8091 Zurich, Switzerland

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

HERPES-SIMPLEX-VIRUS; SARCOMA-ASSOCIATED HERPESVIRUS; NUCLEAR-PORE COMPLEX; DEPENDENT PROTEIN-KINASE; HIV-1; INFECTION; INNATE IMMUNITY; MEDIATED RESISTANCE; ANTIVIRAL ACTIVITY; BINDING MOTIF; WILD-TYPE;

D O I：

10.1038/s41467-018-04379-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi's sarcoma-associated herpesvirus (KSHV). MxB restriction of HSV-1 and HSV-2 requires GTPase function, in contrast to restriction of lentiviruses. MxB inhibits the delivery of incoming HSV-1 DNA to the nucleus and the appearance of empty capsids, but not the capsid delivery to the cytoplasm or tegument dissociation from the capsid. Our study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid.

引用

页数：16

共 79 条

[1] CDNA STRUCTURES AND REGULATION OF 2 INTERFERON-INDUCED HUMAN MX PROTEINS [J].