Percentiles of fasting serum insulin, glucose, HbA1c and HOMA-IR in pre-pubertal normal weight European children from the IDEFICS cohort

被引：117

作者：

Peplies, J. ^{[1
]}

Jimenez-Pavon, D. ^{[2
]}

Savva, S. C. ^{[3
]}

Buck, C. ^{[1
]}

Guenther, K. ^{[1
]}

Fraterman, A. ^{[4
]}

Russo, P. ^{[5
]}

Iacoviello, L. ^{[6
]}

Veidebaum, T. ^{[7
]}

Tornaritis, M. ^{[3
]}

De Henauw, S. ^{[8
]}

Marild, S. ^{[9
]}

Molnar, D. ^{[10
]}

Moreno, L. A. ^{[2
]}

Ahrens, W. ^{[1
,11
]}

机构：

[1] Leibniz Inst Prevent Res & Epidemiol BIPS, D-28359 Bremen, Germany

[2] Univ Zaragoza, Sch Hlth Sci, GENUD Growth Exercise Nutr & Dev Res Grp, Zaragoza, Spain

[3] Res & Educ Inst Child Hlth, Strovolos, Cyprus

[4] Dr Eberhard & Partner Dortmund, Med Versorgungszentrum MVZ, Dortmund, Germany

[5] CNR, Inst Food Sci, Epidemiol & Populat Genet, Avellino, Italy

[6] Univ Cattolica Sacro Cuore, Ctr High Technol Res & Educ Biomed Sci, Campobasso, Italy

[7] NIHD, Tallinn, Estonia

[8] Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium

[9] Queen Silvia Childrens Hosp, Dept Paediat, Gothenburg, Sweden

[10] Univ Pecs, Natl Inst Hlth Promot, Chron Dis Dept, Pecs, Hungary

[11] Univ Bremen, Fac Math & Comp Sci, Inst Stat, D-28359 Bremen, Germany

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2014年 / 38卷

关键词：

HOMEOSTASIS MODEL ASSESSMENT; PEDIATRIC REFERENCE INTERVALS; CARDIOVASCULAR RISK-FACTORS; TYPE-2; DIABETES-MELLITUS; REPRESENTATIVE SAMPLE; GROWTH REFERENCE; REFERENCE VALUES; PLASMA-INSULIN; RESISTANCE; POPULATION;

D O I：

10.1038/ijo.2014.134

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES: The aim of this study is to present age-and sex-specific reference values of insulin, glucose, glycosylated haemoglobin (HbA1c) and the homeostasis model assessment to quantify insulin resistance (HOMA-IR) for pre-pubertal children. METHODS: The reference population consists of 7074 normal weight 3- to 10.9-year-old pre-pubertal children from eight European countries who participated in at least one wave of the IDEFICS ('identification and prevention of dietary-and lifestyle-induced health effects in children and infants') surveys (2007-2010) and for whom standardised laboratory measurements were obtained. Percentile curves of insulin (measured by an electrochemiluminescence immunoassay), glucose, HbA1c and HOMA-IR were calculated as a function of age stratified by sex using the general additive model for location scale and shape (GAMLSS) method. RESULTS: Levels of insulin, fasting glucose and HOMA-IR continuously show an increasing trend with age, whereas HbA1c shows an upward trend only beyond the age of 8 years. Insulin and HOMA-IR values are higher in girls of all age groups, whereas glucose values are slightly higher in boys. Median serum levels of insulin range from 17.4 and 13.2 pmol l(-1) in 3-< 3.5-year-old girls and boys, respectively, to 53.5 and 43.0 pmol l(-1) in 10.5-< 11-year-old girls and boys. Median values of glucose are 4.3 and 4.5 mmol l(-1) in the youngest age group and 49.3 and 50.6 mmol l(-1) in the oldest girls and boys. For HOMA-IR, median values range from 0.5 and 0.4 in 3-< 3.5-year-old girls and boys to 1.7 and 1.4 in 10.5-< 11-year-old girls and boys, respectively. CONCLUSIONS: Our study provides the first standardised reference values for an international European children's population and provides the, up to now, largest data set of healthy pre-pubertal children to model reference percentiles for markers of insulin resistance. Our cohort shows higher values of Hb1Ac as compared with a single Swedish study while our percentiles for the other glucose metabolic markers are in good accordance with previous studies.

引用

页码：S39 / S47

页数：9

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