Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line

被引：58

作者：

Zhang, Zhenya ^{[1
]}

Zhang, Peijuan ^{[1
]}

Hamada, Michito ^{[2
,3
]}

Takahashi, Satoru ^{[2
,3
]}

Xing, Guoqing ^{[1
]}

Liu, Jiqiang ^{[1
]}

Sugiura, Norio ^{[1
]}

机构：

[1] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan

[2] Univ Tsukuba, Dept Anat, Inst Basic Med Sci, Tsukuba, Ibaraki 3058575, Japan

[3] Univ Tsukuba, Dept Embryol, Inst Basic Med Sci, Tsukuba, Ibaraki 3058575, Japan

来源：

ONCOLOGY REPORTS | 2008年 / 20卷 / 05期

关键词：

fucoxanthin; bladder cancer cell; antiproliferative effect; apoptosis; caspase-3; activity;

D O I：

10.3892/or_00000115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bladder cancer is a common but serious malignancy. It is widely accepted that chemoprevention may be an effective way to decrease the rate of recurrence and morbidity. We first determined antigrowth and apoptosis-induction activity of fucoxanthin from dietary Laminaria japonica against EJ-1 human bladder cancers. Fucoxanthin significantly reduced the cell viability in a dose- and time-dependent manner. The induction of apoptosis in EJ-1 cells was characterized by morphological changes, DNA ladder, and increased percentage of hypodiploid cells, activating caspase-3 activity. The ratio of apoptotic cells reached > 93% after treatment for 72 h with 20 mu M fucoxanthin. The findings obtained indicate that fucoxanthin may act as a chemopreventive and/or chemotherapeutic carotenoid in bladder cancer cells by modulating cell viability.

引用

页码：1099 / 1103

页数：5

共 43 条

[1] Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: Formation and cytotoxicity of fucoxanthin metabolites [J].

Asai, A ;

Sugawara, T ;

Ono, H ;

Nagao, A .

DRUG METABOLISM AND DISPOSITION, 2004, 32 (02) :205-211

[2]

Bianchi GD, 2000, AM J EPIDEMIOL, V151, P377, DOI 10.1093/oxfordjournals.aje.a010217

[3] Bladder cancer [J].

Borden, LS ;

Clark, PE ;

Hall, MC .

CURRENT OPINION IN ONCOLOGY, 2003, 15 (03) :227-233

[4]

Bruemmer B, 1996, AM J EPIDEMIOL, V144, P485, DOI 10.1093/oxfordjournals.aje.a008955

[5] Caspases: the executioners of apoptosis [J].

Cohen, GM .

BIOCHEMICAL JOURNAL, 1997, 326 :1-16

[6] A BIOCHEMICAL HALLMARK OF APOPTOSIS - INTERNUCLEOSOMAL DEGRADATION OF THE GENOME [J].

COMPTON, MM .

CANCER AND METASTASIS REVIEWS, 1992, 11 (02) :105-119

[7] Cell death: Critical control points [J].

Danial, NN ;

Korsmeyer, SJ .

CELL, 2004, 116 (02) :205-219

[8]

Glade M.J., 1999, NUTRITION, V15, P523, DOI [10.1016/s0899-9007(99)00021-0, DOI 10.1016/S0899-9007(99)00021-0]

[9] Consumption of black tea and cancer risk: A prospective cohort study [J].

Goldbohm, RA ;

Hertog, MGL ;

Brants, HAM ;

vanPoppel, G ;

vandenBrandt, PA .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1996, 88 (02) :93-100

[10]

HAUGAN JA, 1995, 1A ISOLATION ANAL, P215

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