Association between seasonal factors and multiple sclerosis

被引：19

作者：

Watad, Abdulla ^{[1
,2
]}

Azrielant, Shir ^{[1
,2
]}

Soriano, Alessandra ^{[3
]}

Bracco, Danielle ^{[2
]}

Abu Much, Arsalan ^{[1
,2
]}

Amital, Howard ^{[1
,2
]}

机构：

[1] Sheba Med Ctr, Dept Med B, IL-52621 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[3] Arcispedale Santa Maria Nuova IRCCS, Dept Internal Med, Rheumatol Unit, Reggio Emilia, Italy

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2016年 / 31卷 / 11期

关键词：

Multiple sclerosis; Seasonality; Autoimmunity; Month of birth; Vitamin D; Melatonin; Environment; VITAMIN-D; DISEASE-ACTIVITY; 25-HYDROXYVITAMIN D; DISABILITY STATUS; IMMUNE-SYSTEM; SUN EXPOSURE; RISK-FACTORS; MELATONIN; BIRTH; MRI;

D O I：

10.1007/s10654-016-0165-3

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system. MS is causing progressive and relapsing neurological disability, due to demyelination and axonal damage. The etiopathogenesis of MS is poorly understood. A number of environmental factors have been previously suggested, including: month of birth, vitamin D levels, smoking and viral infections. Previous studies assessing seasonal variation of relapses in multiple sclerosis have had conflicting results. The aim of this review is to assess the association between seasonal factors and MS, in terms of disease onset, relapses and activity.

引用

页码：1081 / 1089

页数：9

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