共 54 条
VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
被引:1479
作者:

Asahara, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Takahashi, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Masuda, H
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Kalka, C
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Chen, DH
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Iwaguro, H
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Inai, Y
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Silver, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Isner, JM
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA
机构:
[1] Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA
[2] Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Biomed Res, Boston, MA 02135 USA
关键词:
blood;
bone marrow;
endothelial progenitor cell;
vascular endothelial growth factor;
vasculogenesis;
D O I:
10.1093/emboj/18.14.3964
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Vascular endothelial growth factor (VEGF) has been shown to promote neovascularization in animal models and, more recently, in human subjects. This feature has been assumed to result exclusively from its direct effects on fully differentiated endothelial cells, i.e. angiogenesis. Given its regulatory role in both angiogenesis and vasculogenesis during fetal development, we investigated the hypothesis that VEGF may modulate endothelial progenitor cell (EPC) kinetics for postnatal neovascularization, Indeed, we observed an increase in circulating EPCs following VEGF administration in vivo. VEGF-induced mobilization of bone marrow-derived EPCs resulted in increased differentiated EPCs irt vitro and augmented corneal neovascularization in vivo. These findings thus establish a novel role for VEGF in postnatal neovascularization which complements its known impact on angiogenesis.
引用
收藏
页码:3964 / 3972
页数:9
相关论文
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