Inflammatory Proteins and the Severity of Dilated Virchow-Robin Spaces in the Elderly

被引：31
作者：
Satizabal, Claudia L. [2 ,3 ]
Zhu, Yi-Cheng [4 ]
Dufouil, Carole [2 ]
Tzourio, Christophe [1 ,2 ]
机构：
[1] Univ Bordeaux 2, INSERM U708, F-33076 Bordeaux, France
[2] INSERM U708 Neuroepidemiol, Bordeaux, France
[3] Univ Paris 06, Paris, France
[4] Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 33卷 / 02期
关键词：
Aged; cerebral small vessel diseases; dilated Virchow-Robin spaces; inflammation; magnetic resonance imaging; C-REACTIVE PROTEIN; ENLARGED PERIVASCULAR SPACES; SMALL VESSEL DISEASE; BRAIN; RISK; MRI; MARKERS; MORTALITY; FAILURE; AGE;
D O I：
10.3233/JAD-2012-120874
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.
引用
收藏
页码：323 / 328
页数：6
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