Unmet Needs for the Treatment of Chronic Hepatitis E Virus Infection in Immunocompromised Patients

被引：4
作者：
Kamar, Nassim [1 ,2 ,3 ]
Del Bello, Arnaud [1 ,2 ]
Abravanel, Florence [2 ,3 ,4 ]
Pan, Qiuwei [5 ,6 ]
Izopet, Jacques [2 ,3 ,4 ]
机构：
[1] CHU Rangueil, Dept Nephrol Dialysis & Organ Transplantat, F-31400 Toulouse, France
[2] Toulouse Inst Infect & Inflammatory Dis Infin, INSERM, UMR 1291, F-31024 Toulouse, France
[3] Univ Paul Sabatier, F-31062 Toulouse, France
[4] CHU Purpan, Lab Virol, F-31300 Toulouse, France
[5] Erasmus MC, Dept Gastroenterol & Hepatol, Univ Med Ctr, NL-3015 GD Rotterdam, Netherlands
[6] Erasmus MC, Transplant Inst, Univ Med Ctr, NL-3015 GD Rotterdam, Netherlands
来源：
VIRUSES-BASEL | 2022年 / 14卷 / 10期
关键词：
hepatitis E virus; organ transplantation; ribavirin; treatment; needs; PEGYLATED INTERFERON-ALPHA; TRANSPLANT RECIPIENTS; LIVER-TRANSPLANT; IN-VITRO; RIBAVIRIN; KIDNEY; HEV; REPLICATION; THERAPY; PREDICTS;
D O I：
10.3390/v14102116
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis E virus (HEV) is the most prevalent hepatitis virus worldwide. Genotypes 3 (HEV3) and 4 (HEV4) as well as rat HEV can lead to chronic hepatitis E and cirrhosis in immunosuppressed patients. Within the last decade, several options for treating chronic hepatitis have been developed and have achieved a sustained virological response. However, there are still unmet needs such as optimizing immunosuppression to allow HEV clearance with or without ribavirin, as well as alternative therapies to ribavirin that are discussed in this paper.
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页数：8
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