Oxygen as an oxidant in rhodium(III) catalyzed oxidative C-H/C-H cross-coupling between indoles and oxazoles

被引:8
作者
Wang, Yan [1 ]
Lan, Jingbo [1 ]
机构
[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
基金
中国国家自然科学基金;
关键词
rhodium catalyzed; molecular oxygen; C-H/C-H cross-coupling; chelation-assisted strategy; MOLECULAR-OXYGEN; 2; HETEROARENES; BOND-CLEAVAGE; SOLE OXIDANT; PALLADIUM; HYDROCARBONS; HETEROCYCLES; DERIVATIVES; 1,3-AZOLES; ACTIVATION;
D O I
10.1007/s11426-017-9053-7
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A Rh(III)-catalyzed oxidative C-H/C-H cross-coupling between indoles and oxazoles with molecular oxygen as an oxidant has been developed to construct a variety of 2-(indol-2-yl)oxazoles. The chelation-assisted strategy endows this catalytic system with an excellent C2-site selectivity by introducing a pyrimidyl directing group. In addition, polycyclic pyridinium salts are also obtained via Rh(III)-catalyzed C-H activation/cyclization of 2-(indol-2-yl)oxazoles with alkynes.
引用
收藏
页码:200 / 205
页数:6
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