Phthalocyanine-Aggregated Polymeric Nanoparticles as Tumor-Homing Near-Infrared Absorbers for Photothermal Therapy of Cancer

被引：88

作者：

Lim, Chang-Keun ^{[1
]}

Shin, Jiyoung ^{[2
]}

Lee, Yong-Deok ^{[1
]}

Kim, Jungahn ^{[3
]}

Oh, Keun Sang ^{[1
]}

Yuk, Soon Hong ^{[4
]}

Jeong, Seo Young ^{[2
]}

Kwon, Ick Chan ^{[1
]}

Kim, Sehoon ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Ctr Theragnosis, Seoul 136791, South Korea

[2] Kyung Hee Univ, Dept Life & Nanophaceut Sci, Seoul 130701, South Korea

[3] Kyung Hee Univ, Dept Chem, Seoul 130701, South Korea

[4] Korea Univ, Coll Pharm, Yeongi 339700, Chungnam, South Korea

来源：

THERANOSTICS | 2012年 / 2卷 / 09期

关键词：

Phototermal therapy; Phthalocyanine; Near-infrared photonics; Tumor targeting; Hyperthermia; Nanoparticles; 808-NM DIODE-LASER; CARBON NANOTUBES; CELL DESTRUCTION; DISC; DYE; POLYCARBONATE; ABLATION; AGENTS; STATE;

D O I：

10.7150/thno.4133

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Phthalocyanine-aggregated Pluronic nanoparticles were constructed as a novel type of near-infrared (NIR) absorber for photothermal therapy. Tiny nanoparticles (similar to 60 nm, FPc NPs) were prepared by aqueous dispersion of phthalocyanine-aggregated self-assembled nanodomains that were phase-separated from the melt mixture with Pluronic. Under NIR laser irradiation, FPc NPs manifested robust heat generation capability, superior to an individual cyanine dye and cyanine-aggregated nanoparticles. Micro-and macroscopic imaging experiments showed that FPc NPs are capable of internalization into live cancer cells as well as tumor accumulation when intravenously administered into living mice. It is shown here that continuous NIR irradiation of the tumor-targeted FPc NPs can cause phototherapeutic effects in vitro and in vivo through excessive local heating, demonstrating potential of phthalocyanine-aggregated nanoparticles as an all-organic NIR nanoabsorber for hyperthermia.

引用

页码：871 / 879

页数：9