Analysis of Neuron-Specific Enolase and S100B as Biomarkers of Cognitive Decline Following Surgery in Older People

被引：13

作者：

Jones, Emma L. ^{[1
]}

Gauge, Nathan ^{[1
]}

Nilsen, Odd Bjarte ^{[4
]}

Lowery, David ^{[3
]}

Wesnes, Keith ^{[5
]}

Katsaiti, Eirini ^{[1
]}

Arden, James ^{[2
]}

Amoako, Derek ^{[2
]}

Prophet, Nicholas ^{[2
]}

Purushothaman, Balaji ^{[2
]}

Green, David ^{[2
]}

Ballard, Clive ^{[1
]}

机构：

[1] Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 1UL, England

[2] Kings Coll Hosp London, Dept Anaesthet, London, England

[3] UCL, Res Dept Primary Care & Populat Hlth, London, England

[4] Stavanger Univ Hosp, Fac Sci & Technol, Stavanger, Norway

[5] Swinburne Univ, Ctr Human Psychopharmacol, Melbourne, Vic, Australia

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2012年 / 34卷 / 5-6期

关键词：

Biological markers; Blood; Risk factors; Geriatric neuropsychiatry; Post-operative cognitive decline; Neuron-specific enolase; S100B protein; CAROTID-ENDARTERECTOMY; BIOCHEMICAL MARKERS; NONCARDIAC SURGERY; GENERAL-ANESTHESIA; ELDERLY-PATIENTS; CARDIAC-SURGERY; BRAIN-DAMAGE; DYSFUNCTION; PROTEIN;

D O I：

10.1159/000345538

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly defined. Methods: Sixty-eight participants over the age of 60 provided blood samples at baseline and 24 h post-surgery. Cognitive decline was measured at baseline and 52 weeks post-surgery using the Cambridge Assessment for Mental Disorder in the Elderly, section B (CAMCOG) score. Plasma levels of neuron-specific enolase (NSE) and S100B were measured by ELISA. Results: Baseline NSE and the change in NSE levels between baseline and 24 h were correlated with the change in CAMCOG score between baseline and 52 weeks. Conclusion: NSE concentrations may be a useful predictor of individuals at risk of more severe long-term cognitive decline. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：307 / 311

页数：5