Analysis of Neuron-Specific Enolase and S100B as Biomarkers of Cognitive Decline Following Surgery in Older People

被引：13
|
作者：
Jones, Emma L. [1 ]
Gauge, Nathan [1 ]
Nilsen, Odd Bjarte [4 ]
Lowery, David [3 ]
Wesnes, Keith [5 ]
Katsaiti, Eirini [1 ]
Arden, James [2 ]
Amoako, Derek [2 ]
Prophet, Nicholas [2 ]
Purushothaman, Balaji [2 ]
Green, David [2 ]
Ballard, Clive [1 ]
机构：
[1] Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 1UL, England
[2] Kings Coll Hosp London, Dept Anaesthet, London, England
[3] UCL, Res Dept Primary Care & Populat Hlth, London, England
[4] Stavanger Univ Hosp, Fac Sci & Technol, Stavanger, Norway
[5] Swinburne Univ, Ctr Human Psychopharmacol, Melbourne, Vic, Australia
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2012年 / 34卷 / 5-6期
关键词：
Biological markers; Blood; Risk factors; Geriatric neuropsychiatry; Post-operative cognitive decline; Neuron-specific enolase; S100B protein; CAROTID-ENDARTERECTOMY; BIOCHEMICAL MARKERS; NONCARDIAC SURGERY; GENERAL-ANESTHESIA; ELDERLY-PATIENTS; CARDIAC-SURGERY; BRAIN-DAMAGE; DYSFUNCTION; PROTEIN;
D O I：
10.1159/000345538
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background/Aims: Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly defined. Methods: Sixty-eight participants over the age of 60 provided blood samples at baseline and 24 h post-surgery. Cognitive decline was measured at baseline and 52 weeks post-surgery using the Cambridge Assessment for Mental Disorder in the Elderly, section B (CAMCOG) score. Plasma levels of neuron-specific enolase (NSE) and S100B were measured by ELISA. Results: Baseline NSE and the change in NSE levels between baseline and 24 h were correlated with the change in CAMCOG score between baseline and 52 weeks. Conclusion: NSE concentrations may be a useful predictor of individuals at risk of more severe long-term cognitive decline. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码：307 / 311
页数：5
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