Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells

被引：75

作者：

Ko, Meehyun ^{[1
]}

Jeon, Sangeun ^{[1
]}

Ryu, Wang-Shick ^{[2
]}

Kim, Seungtaek ^{[1
]}

机构：

[1] Inst Pasteur Korea, Zoonot Virus Lab, Seongnam, South Korea

[2] Inst Pasteur Korea, CEO Off, Seongnam, South Korea

来源：

JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

COVID-19; drug repositioning; FDA-approved drug; SARS-CoV-2;

D O I：

10.1002/jmv.26397

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Drug repositioning represents an effective way to control the current COVID-19 pandemic. Previously, we identified 24 FDA-approved drugs which exhibited substantial antiviral effect against severe acute respiratory syndrome coronavirus 2 in Vero cells. Since antiviral efficacy could be altered in different cell lines, we developed an antiviral screening assay with human lung cells, which is more appropriate than Vero cell. The comparative analysis of antiviral activities revealed that nafamostat is the most potent drug in human lung cells (IC50 = 0.0022 mu M).

引用

页码：1403 / 1408

页数：6

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