Neuregulin-1 and the P300 waveform - A preliminary association study using a psychosis endophenotype

被引：39

作者：

Bramon, Elvira ^{[1
]}

Dempster, Emma ^{[1
,2
]}

Frangou, Sophia ^{[1
]}

Shaikh, Madiha ^{[1
]}

Walshe, Muriel ^{[1
]}

Filbey, Francesca M. ^{[1
,3
]}

McDonald, Colm ^{[1
,4
]}

Sham, Pak ^{[1
,5
]}

Collier, David A. ^{[1
]}

Murray, Robin ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, Div Psychol Med & Psychiat, London SE5 8AF, England

[2] Toronto Western Hosp, Toronto Western Res Inst, Div Cellular & Mol Biol, Toronto, ON M5T 2S8, Canada

[3] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA

[4] Natl Univ Ireland Univ Coll Galway, Inst Clin Sci, Dept Psychiat, Galway, Ireland

[5] Univ Hong Kong, Li Ka Shing Fac Med, Dept Psychiat, Pokfulam, Hong Kong, Peoples R China

来源：

SCHIZOPHRENIA RESEARCH | 2008年 / 103卷 / 1-3期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

D O I：

10.1016/j.schres.2008.03.025

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Neuregulin-1 (NRG1) has been put for-ward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype. Methods: Participants were 64 patients with DSM-IV schizophrenia or schizoaffective disorder, 97 of their non psychotic relatives and 35 unrelated controls. The P300 wave was extracted from the electroencephalogram whilst the subjects conducted a two-tone discrimination task. The effect of three markers from the core NRG-1 at-risk haplotype including single nucleotide polymorphism SNP8NRG221533 and two microsatellites (4781314-848 and 420M9-1395) on P300 amplitude and latency was examined using multilevel modelling. Results: Neuregulin-1 SNP8NRG221533 had a significant influence on P300 latency and the higher the number of C alleles carried, the greater the latency delay [Coef. = 32.4 ms; 95%CI: 13.2 to 51.6 ms; p = 0.001]. There was no association between latency and NRG1 microsatellites or between amplitude and any of the three markers examined. Conclusions: The P300 latency reflects the speed of neural transmission. We hypothesise that variation in NRG1 may convey risk for schizophrenia by disrupting neural connectivity, possibly white matter integrity, and leading to a slower speed of cognitive processing. This is a preliminary finding in a small sample and requires replication. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：178 / 185

页数：8

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