Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability

被引:200
作者
Aso, Yoshinori [1 ]
Herb, Andrea [2 ]
Ogueta, Maite [2 ]
Siwanowicz, Igor [1 ]
Templier, Thomas [1 ]
Friedrich, Anja B. [1 ]
Ito, Kei [3 ]
Scholz, Henrike [2 ,4 ]
Tanimoto, Hiromu [1 ]
机构
[1] Max Planck Inst Neurobiol, Martinsried, Germany
[2] Univ Wurzburg, Lehrstuhl Genet & Neurobiol, Wurzburg, Germany
[3] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo, Japan
[4] Univ Cologne, Biozentrum Koln, D-50931 Cologne, Germany
基金
日本学术振兴会;
关键词
MUSHROOM BODY NEURONS; LONG-TERM-MEMORY; OLFACTORY MEMORY; DROSOPHILA; EXPRESSION; SEROTONIN; BRAIN; LOCALIZATION; DYNAMICS; APLYSIA;
D O I
10.1371/journal.pgen.1002768
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Animals acquire predictive values of sensory stimuli through reinforcement. In the brain of Drosophila melanogaster, activation of two types of dopamine neurons in the PAM and PPL1 clusters has been shown to induce aversive odor memory. Here, we identified the third cell type and characterized aversive memories induced by these dopamine neurons. These three dopamine pathways all project to the mushroom body but terminate in the spatially segregated subdomains. To understand the functional difference of these dopamine pathways in electric shock reinforcement, we blocked each one of them during memory acquisition. We found that all three pathways partially contribute to electric shock memory. Notably, the memories mediated by these neurons differed in temporal stability. Furthermore, combinatorial activation of two of these pathways revealed significant interaction of individual memory components rather than their simple summation. These results cast light on a cellular mechanism by which a noxious event induces different dopamine signals to a single brain structure to synthesize an aversive memory.
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收藏
页数:17
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