Side effects of antibiotics during bacterial infection: Mitochondria, the main target in host cell

被引：95
作者：
Singh, Rochika [1 ]
Sripada, Lakshmi [1 ]
Singh, Rajesh [1 ]
机构：
[1] Indian Inst Adv Res, Sch Biol Sci & Biotechnol, Dept Cell Biol, Gandhinagar 382007, Gujarat, India
来源：
MITOCHONDRION | 2014年 / 16卷
关键词：
Antibiotics; Mitochondria; Side effects; Translational arrest; RIBOSOMAL-RNA GENE; AMINOGLYCOSIDE-INDUCED DEAFNESS; TRANSCRIPTION FACTOR B1; SYNDROMIC HEARING-LOSS; C1494T MUTATION; CHINESE FAMILY; PROTEIN-SYNTHESIS; INHIBITION; DNA; OXAZOLIDINONES;
D O I：
10.1016/j.mito.2013.10.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Antibiotics are frontline therapy against microbial infectious diseases. Many antibiotics are known to cause several side effects in humans. Ribosomal RNA (rRNA) is the main target of antibiotics that inhibit protein synthesis. According to the endosymbiont theory, mitochondrion is of bacterial origin and their molecular and structural components of the protein expression system are almost similar. It has been observed that the rate of mutations in mitochondrial rRNA is higher as compared to that of nuclear rRNA. The presence of these mutations may mimic prokaryotic rRNA structure and bind to antibiotics targeted to ribosomes of bacteria. Mitochondrial functions are compromised hence may be one of the major causes of side effects observed during antibiotic therapy. The current review had summarized the studies on the role of antibiotics on mitochondrial functions and its relevance to the observed side effects in physiological and pathological conditions. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码：50 / 54
页数：5
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