Rho-family GTPases: it's not only Rac and Rho (and I like it)

被引：452

作者：

Wennerberg, K ^{[1
]}

Der, CJ

机构：

[1] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF CELL SCIENCE | 2004年 / 117卷 / 08期

关键词：

Rho; Rac; Cdc42; GTPase; cytoskeleton;

D O I：

10.1242/jcs.01118

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases. To date, 22 human genes encoding at least 25 proteins have been described. The best known 'classical' members are RhoA, Rac1 and Cdc42. Highly related isoforms of these three proteins have not been studied as intensively, in part because it has been assumed that they are functionally identical to their better-studied counterparts. This now appears not to be the case. Variations in C-terminal-signaled modifications and subcellular targeting cause otherwise highly biochemically related isoforms (e.g. RhoA, RhoB and RhoC) to exhibit surprisingly divergent biological activities. Whereas the classical Rho GTPases are regulated by GDP/GTP cycling, other Rho GTPases are also regulated by other mechanisms, particularly by transcriptional regulation. Newer members of the family possess;additional sequence elements beyond the GTPase domain,which suggests they exhibit yet other mechanisms of regulation.

引用

页码：1301 / 1312

页数：12

共 124 条

[11] Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton [J].

Aronheim, A ;

Broder, YC ;

Cohen, A ;

Fritsch, A ;

Belisle, B ;

Abo, A .

CURRENT BIOLOGY, 1998, 8 (20) :1125-1128

[12] XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC [J].

Arthur, WT ;

Ellerbroek, SM ;

Der, CJ ;

Burridge, K ;

Wennerberg, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (45) :42964-42972

[13] Rho GTPases have diverse effects on the organization of the actin filament system [J].

Aspenström, P ;

Fransson, Å ;

Saras, J .

BIOCHEMICAL JOURNAL, 2004, 377 :327-337

[14] Effectors for the Rho GTPases [J].

Aspenström, P .

CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (01) :95-102

[15] The Rac1-and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin [J].

Bellanger, JM ;

Astier, C ;

Sardet, C ;

Ohta, Y ;

Stossel, TP ;

Debant, A .

NATURE CELL BIOLOGY, 2000, 2 (12) :888-892

[16] Rho GTPases and their effector proteins [J].

Bishop, AL ;

Hall, A .

BIOCHEMICAL JOURNAL, 2000, 348 (02) :241-255

[17] RhoGDl-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain [J].

Brunet, N ;

Morin, A ;

Olofsson, B .

TRAFFIC, 2002, 3 (05) :342-357

[18] CODING SEQUENCE OF HUMAN RHO CDNAS CLONE-6 AND CLONE-9 [J].

CHARDIN, P ;

MADAULE, P ;

TAVITIAN, A .

NUCLEIC ACIDS RESEARCH, 1988, 16 (06) :2717-2717

[19] Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice [J].

Chen, Z ;

Sun, JZ ;

Pradines, A ;

Favre, G ;

Adnane, J ;

Sebti, SM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (24) :17974-17978

[20] Cloning and functional characterization of related TC10 isoforms, a subfamily of rho proteins involved in insulin-stimulated glucose transport [J].

Chiang, SH ;

Hou, JC ;

Hwang, J ;

Pessin, JE ;

Saltiel, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (15) :13067-13073

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