Protein-modified hollow copper sulfide nanoparticles carrying indocyanine green for photothermal and photodynamic therapy

被引：82
作者：
Han, Lu [1 ]
Zhang, Yang [1 ]
Chen, Xu-Wei [1 ]
Shu, Yang [1 ,2 ]
Wang, Jian-Hua [1 ]
机构：
[1] Northeastern Univ, Res Ctr Analyt Sci, Coll Sci, Shenyang 110189, Peoples R China
[2] Northeastern Univ, Inst Biotechnol, Coll Life & Hlth Sci, Shenyang 110189, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 01期
关键词：
CELLS IN-VIVO; CANCER-CELLS; SINGLET OXYGEN; DRUG-DELIVERY; ORGANIC NANOPARTICLES; GOLD NANOPARTICLES; ABLATION THERAPY; TUMOR; NANOSPHERES; AGENTS;
D O I：
10.1039/c5tb02002f
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A novel phototherapy nanoplatform is prepared by coating hollow CuS nanoparticles with a bovine serum albumin-folic acid (BSA-FA) complex. The obtained CuS-BSA-FA nanoparticles are used as drug-delivery vehicles to transport a near-infrared-absorbing phototherapeutic agent (indocyanine green, ICG) into HeLa cells, after loading ICG onto CuS-BSA-FA. In this manner, a combined therapy approach is established consisting of photothermal therapy (by CuS-BSA-FA nanocarriers) and cytotoxic effects of photodynamic and photothermal therapy (by ICG upon 808 nm laser irradiation). The encapsulation of ICG onto CuS-BSA-FA significantly improves the stability and reduces the dark toxicity of free ICG. This therapeutic system exhibits an obviously higher photothermal heating effect and capability of O-1(2) generation under laser irradiation compared with bare nanocarriers. In addition, the grafted FA segments on the surface of CuS-BSA-FA are proved to enhance the internalization of nanoparticles by FA-receptor-mediated endocytosis.
引用
收藏
页码：105 / 112
页数：8
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