Nanoscale magnetic resonance imaging

被引：391

作者：

Degen, C. L. ^{[1
]}

Poggio, M. ^{[1
,2
]}

Mamin, H. J. ^{[1
]}

Rettner, C. T. ^{[1
]}

Rugar, D. ^{[1
]}

机构：

[1] Almaden Res Ctr, IBM Res Div, San Jose, CA 95120 USA

[2] Stanford Univ, Ctr Probing Nanoscale, Stanford, CA 94305 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 05期

基金：

美国国家科学基金会; 瑞士国家科学基金会;

关键词：

MRFM; MRI; nuclear magnetic resonance; molecular structure imaging; MOSAIC-VIRUS PARTICLE; NUCLEAR-SPIN NOISE; FORCE MICROSCOPY; MECHANICAL DETECTION; RESOLUTION;

D O I：

10.1073/pnas.0812068106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have combined ultrasensitive magnetic resonance force microscopy (MRFM) with 3D image reconstruction to achieve magnetic resonance imaging (MRI) with resolution < 10 nm. The image reconstruction converts measured magnetic force data into a 3D map of nuclear spin density, taking advantage of the unique characteristics of the "resonant slice" that is projected outward from a nanoscale magnetic tip. The basic principles are demonstrated by imaging the H-1 spin density within individual tobacco mosaic virus particles sitting on a nanometer-thick layer of adsorbed hydrocarbons. This result, which represents a 100 million-fold improvement in volume resolution over conventional MRI, demonstrates the potential of MRFM as a tool for 3D, elementally selective imaging on the nanometer scale.

引用

页码：1313 / 1317

页数：5

共 39 条

[1] CRYO-ELECTRON MICROSCOPY OF VIRUSES [J].