Chemical constituents from the fruits of Psoralea corylifolia and their protective effects on ionising radiation injury

被引：15

作者：

Du, Jie ^{[1
]}

Wang, Chun-Hua ^{[1
,2
]}

Yang, Jing ^{[1
]}

He, Xin ^{[3
,4
]}

Han, Xiao-Liang ^{[5
]}

Li, Cong-Cong ^{[1
]}

Chai, Xin ^{[1
]}

Wang, Yue-Fei ^{[1
]}

Zhu, Yan ^{[1
]}

Li, Zheng ^{[2
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Tianjin Key Lab Modern Chinese Med, Tianjin, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, Tianjin, Peoples R China

[3] Peking Union Med Coll, Inst Radiat Med, Tianjin, Peoples R China

[4] Chinese Acad Med Sci, Tianjin, Peoples R China

[5] North China Univ Sci & Technol, Affiliated Hosp, Dept Anesthesiol, Tangshan, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Corylifol F; corylifol G; Psoralea corylifolia L; anti-radiation; COUMESTAN; CHALCONES; PLANTS;

D O I：

10.1080/14786419.2017.1405407

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new flavonoids, corylifol F (1) and corylifol G (2), together with 19 known compounds, were isolated from the fruits of Psoralea corylifolia L.. The structures of these compounds were determined by interpretation of spectroscopic data and comparison with literature properties. The radioprotective effects of the isolated compounds against ionising radiation damage were also evaluated in vitro. The results showed that corylifol A exhibited radioprotective effects in both HBL-100 and MCF-7 cells, while psoralen, isopsoralen, corylifol C and bakuchiol showed obvious selective action to protect HBL-100 cells against damage caused by ionising radiation. [GRAPHICS] .

引用

页码：673 / 680

页数：8

共 27 条

[1]

[Anonymous], 2016, ELECTRON J DIFFER EQ

[2]

Cui Yan-jun, 2002, Yaoxue Xuebao, V37, P784

[3] Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus [J].

Cui, Yanmei ;

Taniguchi, Shoko ;

Kuroda, Teruo ;

Hatano, Tsutomu .

MOLECULES, 2015, 20 (07) :12500-12511

[4]

Guo Jiangning, 2003, Zhong Yao Cai, V26, P185

[5] FLAVONOIDS IN ROOTS OF SOPHORA-PROSTRATA [J].

IINUMA, M ;

OHYAMA, M ;

TANAKA, T .

PHYTOCHEMISTRY, 1995, 38 (02) :539-543

[6]

Jia HQ, 2010, J PREV MED CHIN PLA, V28, P4

[7]

Jun B., 2010, CHIN ARCH TRADITIONA, V28, P1747

[8]

KONDO Y, 1990, HETEROCYCLES, V31, P187

[9] Microbial transformation of prenylflavonoids from Psoralea corylifolia by using Cunninghamella blakesleeana and C. elegans [J].

Ma, Shunan ;

Zheng, Cheng ;

Feng, Li ;

Huang, Youwu ;

Wang, Rui ;

Huang, Cheng ;

Li, Yiming ;

Guo, Fujiang .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2015, 118 :8-15

[10] Medicinal plants with anti-inflammatory activities [J].

Maione, Francesco ;

Russo, Rosa ;

Khan, Haroon ;

Mascolo, Nicola .

NATURAL PRODUCT RESEARCH, 2016, 30 (12) :1343-1352

← 1 2 3 →