Long-term follow-up of cervical dystonia patients treated with botulinum toxin A

被引：79

作者：

Haussermann, P ^{[1
]}

Marczoch, S ^{[1
]}

Klinger, C ^{[1
]}

Landgrebe, M ^{[1
]}

Conrad, B ^{[1
]}

Ceballos-Baumann, A ^{[1
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-81675 Munich, Germany

来源：

MOVEMENT DISORDERS | 2004年 / 19卷 / 03期

关键词：

cervical dystonia; botulinum toxin A; long-term outcome;

D O I：

10.1002/mds.10659

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We followed the course in 100 consecutive patients with cervical dystonia (CD) after they were initially treated with botulinum toxin (BTX) in the form of Dysport 10 to 12 years ago. A total of 4 patients had died, and 6 were lost to follow-up. Of the remaining 90 patients, 57 (63%) were still treated with BTX. In the patients treated at one centre over the whole period with Dysport, mean dose used during each treatment session was 833 (SD +/- 339) units Dysport with a cumulative dose of 20,943 (SD +/- 9462) units Dysport over a mean of 26.8 (SD +/- 8.6) treatment cycles. Secondary nonresponse was detected in 3 of the 90 patients. During follow-up, 12 patients developed blepharospasm, 13 oromandibular dystonia, and 17 patients writer's cramp. We conclude that BTX remains effective and safe for approximately 60% of CD patients for more than 10 years. (C) 2004 Movement Disorder Society.

引用

页码：303 / 308

页数：6