Immunological cure of HBV infection

被引：42

作者：

Lang, Julia ^{[1
]}

Neumann-Haefelin, Christoph ^{[1
]}

Thimme, Robert ^{[1
]}

机构：

[1] Univ Hosp Freiburg, Fac Med, Dept Med 2, Hugstetter Str 55, D-79106 Freiburg, Germany

来源：

HEPATOLOGY INTERNATIONAL | 2019年 / 13卷 / 02期

关键词：

Adaptive immunity; CD4+T-lymphocytes; CD8+T-lymphocytes; Hepatitis B; Immunotherapy; HEPATITIS-B-VIRUS; CD8(+) T-CELLS; SURFACE-ANTIGEN SEROCLEARANCE; IMMUNE-RESPONSES; VIRAL CLEARANCE; THERAPEUTIC VACCINATION; INNATE IMMUNITY; PATHOGENESIS; REACTIVATION; INTERFERON;

D O I：

10.1007/s12072-018-9912-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeutic strategies. Based on the current evidence on immunology in resolving and persistent HBV infection, we will review the growing field of immunotherapeutic approaches for treatment of chronic HBV infection. We will also discuss the challenge of a heterogeneous patient population and personalized treatment as a possible key factor of success. [GRAPHICS]

引用

页码：113 / 124

页数：12

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