Prenatal Management of Congenital Human Cytomegalovirus Infection in Seropositive Pregnant Patients Treated with Azathioprine

被引：7

作者：

Cavoretto, Paolo Ivo ^{[1
,2
]}

Fornara, Chiara ^{[3
]}

Baldoli, Cristina ^{[4
]}

Arossa, Alessia ^{[5
]}

Furione, Milena ^{[6
]}

Candiani, Massimo ^{[1
,2
]}

Rovere Querini, Patrizia ^{[7
]}

Barera, Graziano ^{[2
,8
]}

Poloniato, Antonella ^{[2
,8
]}

Gaeta, Gerarda ^{[1
,2
]}

Spinillo, Arsenio ^{[5
]}

Lilleri, Daniele ^{[3
]}

机构：

[1] IRCCS San Raffaele Hosp, Obstest & Gynaecol Dept, Via Olgettina 60, I-20132 Milan, Italy

[2] Univ Milan, Via Olgettina 60, I-20132 Milan, Italy

[3] Fdn IRCCS Policlin San Matteo, Lab Genet Transplantat & Cardiovasc Dis, I-27100 Pavia, Italy

[4] IRCCS San Raffaele Hosp, Dept Neuroradiol, Via Olgettina 60, I-20132 Milan, Italy

[5] Fdn IRCCS Policlin San Matteo, Obstest & Gynaecol, I-27100 Pavia, Italy

[6] Fdn IRCCS Policlin San Matteo, Microbiol & Virol, Mol Virol, I-27100 Pavia, Italy

[7] IRCCS San Raffaele Hosp, Div Immunol Transplantat & Infect Dis, Dept Internal Med, Autoimmun & Gender Med Unit, Via Olgettina 60, I-20132 Milan, Italy

[8] IRCCS San Raffaele Hosp, Neonatol & Pediat Dept, Via Olgettina 60, I-20132 Milan, Italy

来源：

DIAGNOSTICS | 2020年 / 10卷 / 08期

关键词：

congenital cytomegalovirus infection; azathioprine; pregnancy; ultrasound; fetal MRI; T-CELLS;

D O I：

10.3390/diagnostics10080542

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human cytomegalovirus (HCMV) is the leading infectious agent causing congenital disabilities. The risk of HCMV transmission to the fetus in pregnant women receiving immunosuppressive agents is unknown. We describe two cases of pregnant women with evidence of pre-conception HCMV protective immunity receiving azathioprine for ulcerative colitis or systemic lupus erythematosus. Both women reactivated the HCMV and transmitted the infection to the fetuses. One newborn showed unilateral hearing deficits and brain abnormalities while the other was asymptomatic. The mother of the symptomatic newborn had low levels of total and HCMV-specific blood CD4(+)T cells. Women receiving immunosuppressive agents deserve information about the risk of HCMV congenital infection and should be monitored for HCMV infection during pregnancy. Their newborns should be screened for HCMV congenital infection.

引用

页数：9

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