Synthesis, crystal structure, DNA-binding properties, and antioxidant activity of a V-shaped ligand bis(N-methylbenzimidazol-2-ylmethyl)benzylamine and its zinc(II) complex

被引：16
作者：
Wu, Huilu [1 ,2 ]
Yuan, Jingkun [2 ]
Bai, Ying [2 ]
Pan, Guolong [2 ]
Wang, Hua [2 ]
Shao, Juanhui [2 ]
Gao, Jiali [2 ]
Wang, Yaoyu [1 ]
机构：
[1] Northwest Univ, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Coll Chem & Mat Sci, Xian 710069, Peoples R China
[2] Lanzhou Jiaotong Univ, Sch Chem & Biol Engn, Lanzhou 730070, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2012年 / 65卷 / 24期
关键词：
Benzimidazole; Zinc(II) complex; Crystal structure; DNA-binding property; Antioxidant property; TRANSITION-METAL-COMPLEXES; BENZOYL HYDRAZONE; COPPER(II) COMPLEXES; RUTHENIUM COMPLEXES; HYDROXYL RADICALS; ZN(II) COMPLEXES; HALIDE-COMPLEXES; CU(II) COMPLEX; SCHIFF-BASES; SOLID-STATE;
D O I：
10.1080/00958972.2012.741229
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A V-shaped ligand bis(N-methylbenzimidazol-2-ylmethyl)benzylamine (L) and its zinc(II) complex, [ZnL 2](pic)2?.?2CH3CN (pic?=?picrate), have been synthesized and characterized by physico-chemical and spectroscopic methods. Single-crystal X-ray crystallographic analysis revealed that the Zn(II) complex possesses a distorted trigonal bipyramidal geometry. Supramolecular interactions arising from various intra- or intermolecular p center dot center dot center dot p stacking interactions contributed to the form of the multidimensional configuration. Interactions of L and Zn(II) complex with DNA were monitored using spectrophotometric methods and viscosity measurements. The results suggest that L and Zn(II) complex both bind to DNA via intercalation and Zn(II) complex binds to DNA more strongly than L. Moreover, the Zn(II) complex also exhibited potential antioxidant properties in vitro.
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页码：4327 / 4341
页数：15
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