Cholesteryl Ester Transfer Protein and Lipid Metabolism and Cardiovascular Diseases

被引：21

作者：

Oliveira, Helena C. F. ^{[1
]}

Raposo, Helena F. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas, SP, Brazil

来源：

LIPID TRANSFER IN LIPOPROTEIN METABOLISM AND CARDIOVASCULAR DISEASE | 2020年 / 1276卷

基金：

巴西圣保罗研究基金会;

关键词：

Cholesteryl ester transfer protein (CETP); Lipoprotein metabolism; Lipid metabolism; CETP inhibitors; Cardiovascular diseases; HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; CETP EXPRESSION; ATHEROSCLEROTIC LESIONS; TRANSGENIC MICE; BINDING PROTEINS; MESSENGER-RNA; HIGH-RISK; DEFICIENCY; ASSOCIATION;

D O I：

10.1007/978-981-15-6082-8_2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this chapter, we present the major advances in CETP research since the detection, isolation, and characterization of its activity in the plasma of humans and several species. Since CETP is a major modulator of HDL plasma levels, the clinical importance of CETP activity was recognized very early. We describe the participation of CETP in reverse cholesterol transport, conflicting results in animal and human genetic studies, possible new functions of CETP, and the results of the main clinical trials on CETP inhibition. Despite major setbacks in clinical trials, the hypothesis that CETP inhibitors are anti-atherogenic in humans is still being tested.

引用

页码：15 / 25

页数：11

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