Spy vs. spy: selecting the best reporter for 19F NMR competition experiments

被引：22

作者：

de Castro, Guilherme Vieira ^{[1
]}

Ciulli, Alessio ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Div Biol Chem & Drug Discovery, Dow St, Dundee DD1 5EH, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 10期

基金：

欧洲研究理事会; 英国惠康基金;

关键词：

E3 UBIQUITIN LIGASE; PROTEIN-PROTEIN INTERACTION; STRUCTURE-GUIDED DESIGN; SMALL MOLECULES; DRUG DISCOVERY; LEAD DISCOVERY; AFFINITY; OPTIMIZATION; LIBRARY; BINDING;

D O I：

10.1039/c8cc09790a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive F-19 NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

引用

页码：1482 / 1485

页数：4

共 23 条

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[23] iClick Reactions of Square-Planar Palladium(II) and Platinum(II) Azido Complexes with Electron-Poor Alkynes: Metal-Dependent Preference for N1 vs N2 Triazolate Coordination and Kinetic Studies with 1H and 19F NMR Spectroscopy
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