A New Prenylated Isoflavone and a New Flavonol Glycoside from Flemingia philippinensis

被引：13

作者：

Fu, Manqin ^{[1
,2
]}

Feng, Shixiu ^{[1
,2
]}

Zhang, Nenling ^{[1
,2
]}

Zhou, Xiaojun ^{[1
,3
]}

Huang, Riming ^{[1
]}

Huang, Huijuan ^{[1
,4
]}

Xu, Zhifang ^{[1
]}

Li, Xu-e ^{[4
]}

Qiu, Samuel X. ^{[1
]}

机构：

[1] Chinese Acad Sci, S China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

[3] Nanchang Univ, Coll Med, Dept Pharm, Nanchang 330006, Peoples R China

[4] S China Normal Univ, Guangdong Prov Key Lab Biotechnol Plant Dev, Guangzhou 510631, Guangdong, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2012年 / 95卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Flemingia philippinensis; Isoflavonoids; Flavonol glycosides; Flemiphilippinin G; Flemiphilippininside; Glycosides; ERYTHRINA;

D O I：

10.1002/hlca.201100360

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new prenylated isoflavonoid, flemiphilippinin G (1), and a new flavonol glycoside, flemiphilippininside (2), along with eleven known isoflavonoids were obtained from the roots of Flemingia philippinensis (Merr. et Rolfe) Li. Their structures were elucidated on the basis of spectroscopic data. The in vitro cytotoxicities of compounds 113 against MCF-7, A549, and Hep-G2 cell lines were determined by using the MTT (=3-(4,5-dimethylthazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) colorimetric assay, and their antioxidant activities were evaluated by ferric-reducing antioxidant power (FRAP) method. Compound 1 exhibited significant cytotoxicity against all the tested cell lines with IC50 values of 4.87.3 mu M, and compound 2 was found to be inactive. Both compounds 1 and 2 showed weak antioxidant activities with FRAP values of 110+/-15 and 124+/-16 mu mol/g, respectively.

引用

页码：598 / 605

页数：8

共 14 条

[1] Estrogenic and antiestrogenic activities of the roots of Moghania philippinensis and their constituents [J].