Vitamin E: A dark horse at the crossroad of cancer management

被引:60
作者
Cardenas, Eduardo [1 ]
Ghosh, Rita [1 ,2 ,3 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Dept Urol, San Antonio, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Dept Pharmacol, San Antonio, TX 78229 USA
[3] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA
关键词
Tocopherol; Tocotrienol; Vitamin E transport proteins; Antioxidant; Cancer prevention; Cancer therapy; TOCOPHEROL TRANSFER PROTEIN; ALPHA-TOCOPHEROL; PROSTATE-CANCER; GAMMA-TOCOPHEROL; BETA-CAROTENE; BREAST-CANCER; LIPID-PEROXIDATION; DELTA-TOCOTRIENOL; COLORECTAL-CANCER; CELL-GROWTH;
D O I
10.1016/j.bcp.2013.07.018
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
It appears that the story on vitamin E and its role in human health remains incomplete. It is apparent that vitamin E supplementation involves many variables, some of which include its uptake from the intestine, the preference for a-tocopherol, transport by tocopherol specific proteins and lipid transporters and the differential metabolism of different vitamin E isoforms. The fundamental differences within population genetics can have significant implications for the effect that dietary supplementation might have on human health. When evaluating the efficacy of vitamin E prophylactic or therapeutic use in previous and future studies, it is critical to consider dosage to be administered, form of vitamin E and source (such as whether from synthetic or purified from natural sources). Further studies are needed to determine the effects of all vitamin E isoforms on cell growth, tumorigenicity, to clarify its possible use as an adjuvant to existing chemotherapeutics. The Alpha-Tocopherol, Beta Carotene (ATBC) Cancer Prevention Study Group and Selenium and Vitamin E Cancer Prevention Trial (SELECT) studies along with the numerous studies of vitamin E should help guide the next chapter of vitamin E research. (c) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:845 / 852
页数:8
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