Study on the association between CTD peptides and zinc(II)-dipicolylamine appended beta-cyclodextrin

被引：3
|
作者：
Zhang, Saihui [1 ,2 ,3 ]
Shi, Yantao [1 ,2 ]
Wang, Wei [1 ,2 ]
Yuan, Zhi [1 ,2 ]
机构：
[1] Nankai Univ, Inst Polymer Chem, Minist Educ, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China
[2] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
[3] Tianjin Polytechn Univ, Sch Environm & Chem Engn, State Key Lab Separat Membranes & Membrane Proc, Tianjin 300387, Peoples R China
来源：
RSC ADVANCES | 2015年 / 5卷 / 98期
基金：
中国国家自然科学基金;
关键词：
RNA-POLYMERASE-II; MOLECULAR RECOGNITION; TERMINAL DOMAIN; PHOSPHATASE; HYDROLYSIS; RECEPTORS;
D O I：
10.1039/c5ra12374g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Association between zinc(II)-dipicolylamine (ZnDpa) appended beta-cyclodextrin (beta-CD) and CTD (carboxy-terminal domain of RNA polymerase II) peptides with different phosphorylation patterns was studied by isothermal titration calorimetry (ITC) and nuclear magnetic resonance (NMR). The receptor displayed association constants of 6.52 x 10(3) to 1.49 x 10(5) towards the phosphorylated peptides, which are 16 to 72 times higher than that of ZnDpa, indicating the involvement of molecular recognition of beta-CD. NMR results confirm the involvement of beta-CD in the association, i.e. the aromatic ring on the tyrosine of the peptide was included in the cavity of CD, while the inclusion manners are different among the peptides.
引用
收藏
页码：80434 / 80440
页数：7
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