Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways

被引：59

作者：

Gao, Feng ^{[1
,2
]}

Yao, Min ^{[3
]}

Shi, Yonghong ^{[1
]}

Hao, Jun ^{[1
]}

Ren, Yunzhuo ^{[1
]}

Liu, Qingjuan ^{[1
]}

Wang, Xiaomeng ^{[2
]}

Duan, Huijun ^{[1
]}

机构：

[1] Hebei Med Univ, Dept Pathol, Shijiazhuang 050017, Hebei, Peoples R China

[2] Hebei Med Univ, Hosp 3, Dept Pathol, Shijiazhuang 050051, Peoples R China

[3] Hebei Med Univ, Dept Biochem, Shijiazhuang 050017, Hebei, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2013年 / 114卷 / 05期

基金：

中国国家自然科学基金;

关键词：

HIGH GLUCOSE; NOTCH PATHWAY; PODOCYTES; Bcl-2; p53; APOPTOSIS; CELL-CYCLE ARREST; MESANGIAL CELLS; DIABETIC-NEPHROPATHY; GROWTH; EXPRESSION; KIDNEY; DIFFERENTIATION; TGF-BETA-1; RECEPTOR; STRESS;

D O I：

10.1002/jcb.24442

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have shown that Notch pathway plays a key role in the pathogenesis of diabetic nephropathy (DN), however, the exact mechanisms remain elusive. Here we demonstrated that high glucose (HG) upregulated Notch pathway in podocytes accompanied with the alteration of Bcl-2 and p53 pathways, subsequently leading to podocytes apoptosis. Inhibition of Notch pathway by chemical inhibitor or specific short hairpin RNA (shRNA) vector in podocytes prevented Bcl-2- and p53-dependent cell apoptosis. These findings suggest that Notch pathway mediates HG-induced podocytes apoptosis via Bcl-2 and p53 pathways. J. Cell. Biochem. 114: 10291038, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：1029 / 1038

页数：10

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