Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways

被引：59

作者：

Gao, Feng ^{[1
,2
]}

Yao, Min ^{[3
]}

Shi, Yonghong ^{[1
]}

Hao, Jun ^{[1
]}

Ren, Yunzhuo ^{[1
]}

Liu, Qingjuan ^{[1
]}

Wang, Xiaomeng ^{[2
]}

Duan, Huijun ^{[1
]}

机构：

[1] Hebei Med Univ, Dept Pathol, Shijiazhuang 050017, Hebei, Peoples R China

[2] Hebei Med Univ, Hosp 3, Dept Pathol, Shijiazhuang 050051, Peoples R China

[3] Hebei Med Univ, Dept Biochem, Shijiazhuang 050017, Hebei, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2013年 / 114卷 / 05期

基金：

中国国家自然科学基金;

关键词：

HIGH GLUCOSE; NOTCH PATHWAY; PODOCYTES; Bcl-2; p53; APOPTOSIS; CELL-CYCLE ARREST; MESANGIAL CELLS; DIABETIC-NEPHROPATHY; GROWTH; EXPRESSION; KIDNEY; DIFFERENTIATION; TGF-BETA-1; RECEPTOR; STRESS;

D O I：

10.1002/jcb.24442

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have shown that Notch pathway plays a key role in the pathogenesis of diabetic nephropathy (DN), however, the exact mechanisms remain elusive. Here we demonstrated that high glucose (HG) upregulated Notch pathway in podocytes accompanied with the alteration of Bcl-2 and p53 pathways, subsequently leading to podocytes apoptosis. Inhibition of Notch pathway by chemical inhibitor or specific short hairpin RNA (shRNA) vector in podocytes prevented Bcl-2- and p53-dependent cell apoptosis. These findings suggest that Notch pathway mediates HG-induced podocytes apoptosis via Bcl-2 and p53 pathways. J. Cell. Biochem. 114: 10291038, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：1029 / 1038

页数：10

共 50 条

[1] MicroRNA-145-5p attenuates high glucose-induced apoptosis by targeting the Notch signaling pathway in podocytes
Wei, Bing
Liu, Yi-Song
Guan, Hai-Xia
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2020, 19 (03) : 1915 - 1924
[2] MicroRNA-134-5p promotes high glucose-induced podocyte apoptosis by targeting bcl-2
Qian, Xiaoxiao
Tan, Juan
Liu, Ling
Chen, Sheng
You, Na
Yong, Huijuan
Pan, Minglin
You, Qiang
Ding, Dafa
Lu, Yibing
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2018, 10 (03): : 989 - 997
[3] Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis
Wang, Xiao-Mei
Yao, Min
Liu, Shu-Xia
Hao, Jun
Liu, Qing-Juan
Gao, Feng
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2014, 306 (02) : F205 - F213
[4] Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway
Yao, Min
Gao, Feng
Wang, Xiaomeng
Shi, Yonghong
Liu, Shuxia
Duan, Huijun
MOLECULAR MEDICINE REPORTS, 2017, 15 (06) : 4319 - 4325
[5] Overexpression of miR-34c inhibits high glucose-induced apoptosis in podocytes by targeting Notch signaling pathways
Liu, Xiang-Dong
Zhang, Lian-Yun
Zhu, Tie-Chui
Zhang, Rui-Fang
Wang, Shu-Long
Bao, Yan
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (05): : 4525 - 4534
[6] c-Abl contributes to glucose-promoted apoptosis via p53 signaling pathway in podocytes
Ma, Yiqiong
Yang, Qian
Chen, Xinghua
Liang, Wei
Ren, Zhilong
Ding, Guohua
DIABETES RESEARCH AND CLINICAL PRACTICE, 2016, 113 : 171 - 178
[7] SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway
Chen, Tongshuai
Ma, Chang
Fan, Guanqi
Liu, Hui
Lin, Xie
Li, Jingyuan
Li, Na
Wang, Shujian
Zeng, Mei
Zhang, Yun
Bu, Peili
LIFE SCIENCES, 2021, 264
[8] Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis
Li, Guang-Yu
Xie, Ping
Li, Hui-Ying
Hao, Le
Xiong, Qian
Qiu, Tong
ENVIRONMENTAL TOXICOLOGY, 2011, 26 (02) : 111 - 117
[9] Nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes
沈剑刚
丘幸生
姜泊
张德良
忻文娟
赵保路
Science in China(Series C:Life Sciences), 2003, (01) : 28 - 39
[10] Nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes
Shen, JG
Qiu, XS
Jiang, B
Zhang, DL
Xin, WJ
Fung, PCW
Zhao, BL
SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 2003, 46 (01): : 28 - 39

← 1 2 3 4 5 →