Quality of life in long-term breast cancer survivors - a 10-year longitudinal population-based study

被引:137
作者
Koch, Lena [1 ]
Jansen, Lina [1 ]
Herrmann, Antje [1 ]
Stegmaier, Christa [2 ]
Holleczek, Bernd [2 ]
Singer, Susanne [3 ]
Brenner, Hermann [1 ]
Arndt, Volker [1 ]
机构
[1] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69009 Heidelberg, Germany
[2] Saarland Canc Registry, Saarbrucken, Germany
[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat, Div Epidemiol & Hlth Serv Res, D-55122 Mainz, Germany
关键词
EUROPEAN-ORGANIZATION; EORTC QLQ-C30; HEALTH; PERSISTENCE; MASTECTOMY; NATIONWIDE; DIAGNOSIS; PROSTATE; SURGERY; COHORT;
D O I
10.3109/0284186X.2013.774461
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background. Breast cancer survivors may experience adverse effects of cancer and/or treatment years after completion of therapy, which can considerably decrease quality of life (QoL). Little is known about the time course of QoL in breast cancer survivors beyond the fifth year post-diagnosis, when routine follow-up care has usually terminated. We therefore explored in detail whether and to what extent restrictions in breast cancer survivors persist and whether changes or aggravations in QoL occurred over time. Material and methods. QoL was assessed 1, 3, 5, and 10 years post-diagnosis in a population-based cohort of initially 387 female breast cancer patients from Saarland (Germany), using the EORTC QLQ-C30 and QLQ-BR23. Time course of QoL over 10 years post-diagnosis was assessed for survivors and survivors' QoL was compared cross-sectionally to the German general population after adjustment for age. Results. A total of 182 out of 238 patients alive (76.5%) responded in the 10-year, 160 patients (67.2%) participated in all follow-ups. Although breast cancer survivors and controls reported comparable general health and overall QoL, survivors reported significantly more restrictions on most functioning and symptom scales at each follow-up. Detriments in various QoL dimensions (e.g. physical and social functioning; pain, financial difficulties) aggravated from year 5 to 10. Generally, restrictions were largest for the youngest survivors. Conclusion. Relevant restrictions in QoL persist over years in breast cancer survivors and affect predominantly younger women. The aggravation of restrictions in QoL beyond the fifth year may indicate deficits in health care and psychosocial support of breast cancer patients after completion of routine follow-up care.
引用
收藏
页码:1119 / 1128
页数:10
相关论文
共 34 条
[1]   THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].
AARONSON, NK ;
AHMEDZAI, S ;
BERGMAN, B ;
BULLINGER, M ;
CULL, A ;
DUEZ, NJ ;
FILIBERTI, A ;
FLECHTNER, H ;
FLEISHMAN, SB ;
DEHAES, JCJM ;
KAASA, S ;
KLEE, M ;
OSOBA, D ;
RAZAVI, D ;
ROFE, PB ;
SCHRAUB, S ;
SNEEUW, K ;
SULLIVAN, M ;
TAKEDA, F .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376
[2]  
Altekruse SF KC., 2010, SEER Cancer Statistics Review
[3]   Persistence of restrictions in quality of life from the first to the third year after diagnosis in women with breast cancer [J].
Arndt, V ;
Merx, H ;
Stegmaier, C ;
Ziegler, H ;
Brenner, H .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (22) :4945-4953
[4]   Age-specific detriments to quality of life among breast cancer patients one year after diagnosis [J].
Arndt, V ;
Merx, H ;
Stürmer, T ;
Stegmaier, C ;
Ziegler, H ;
Brenner, H .
EUROPEAN JOURNAL OF CANCER, 2004, 40 (05) :673-680
[5]   Quality of life over 5 years in women with breast cancer after breast-conserving therapy versus mastectomy: a population-based study [J].
Arndt, Volker ;
Stegmaier, Christa ;
Ziegler, Hartwig ;
Brenner, Hermann .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2008, 134 (12) :1311-1318
[6]   Cancer survivorship research: State of knowledge, challenges and opportunities [J].
Aziz, Noreen M. .
ACTA ONCOLOGICA, 2007, 46 (04) :417-432
[7]   Effects of Surgical and Adjuvant Therapies for Breast Cancer on Sexuality, Cognitive Functions, and Body Weight [J].
Biglia, Nicoletta ;
Moggio, Giulia ;
Peano, Elisa ;
Sgandurra, Paola ;
Ponzone, Riccardo ;
Nappi, Rossella E. ;
Sismondi, Piero .
JOURNAL OF SEXUAL MEDICINE, 2010, 7 (05) :1891-1900
[8]   Multi-dimensional quality of life among long-term (5+years) adult cancer survivors [J].
Bloom, Joan R. ;
Petersen, Dana M. ;
Kang, Soo H. .
PSYCHO-ONCOLOGY, 2007, 16 (08) :691-706
[9]   Quality of life of younger breast cancer survivors: persistence of problems and sense of well-being [J].
Bloom, Joan R. ;
Stewart, Susan L. ;
Oakley-Girvan, Ingrid ;
Banks, Priscilla J. ;
Shema, Sarah .
PSYCHO-ONCOLOGY, 2012, 21 (06) :655-665
[10]   Then and now: Quality of life of young breast cancer survivors [J].
Bloom, JR ;
Stewart, SL ;
Chang, S ;
Banks, PJ .
PSYCHO-ONCOLOGY, 2004, 13 (03) :147-160