A multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors

被引：10

作者：

Isohashi, Fumiaki ^{[1
]}

Takano, Tadao ^{[2
]}

Onuki, Mamiko ^{[3
]}

Arimoto, Takahide ^{[4
]}

Kawamura, Naoki ^{[5
]}

Hara, Ryusuke ^{[6
]}

Kawano, Yoshiaki ^{[7
]}

Ota, Yukinobu ^{[8
]}

Inokuchi, Haruo ^{[9
]}

Shinjo, Hidenori ^{[10
]}

Saito, Toshiaki ^{[11
]}

Fujiwara, Satoe ^{[12
]}

Sawasaki, Takashi ^{[13
]}

Ando, Ken ^{[14
]}

Horie, Koji ^{[15
]}

Okamoto, Hiroyuki ^{[16
]}

Murakami, Naoya ^{[16
]}

Hasumi, Yoko ^{[17
]}

Kasamatsu, Takahiro ^{[18
]}

Toita, Takafumi ^{[19
]}

机构：

[1] Osaka Univ, Dept Radiat Oncol, Grad Sch Med, 2-2,D10 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Tohoku Univ, Dept Gynecol & Obstet, Grad Sch Med, Sendai, Miyagi, Japan

[3] Univ Tsukuba, Fac Med, Dept Obstet & Gynecol, Tsukuba, Ibaraki, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[5] Osaka City Gen Hosp, Dept Gynecol, Osaka, Japan

[6] Chiba Canc Ctr, Div Radiat Oncol, Chiba, Japan

[7] Kyushu Univ, Grad Sch Med Sci, Dept Gynecol & Obstet, Fukuoka, Fukuoka, Japan

[8] Osaka Int Canc Inst, Dept Gynecol, Osaka, Japan

[9] Kyoto Univ, Grad Sch Med, Dept Radiat Oncol & Image Appl Therapy, Kyoto, Japan

[10] Showa Univ Hosp, Dept Radiat Oncol, Tokyo, Japan

[11] Natl Kyushu Canc Ctr, Gynecol Serv, Fukuoka, Fukuoka, Japan

[12] Osaka Med Coll, Dept Obstet & Gynecol, Osaka, Japan

[13] Natl Hosp Org Kure Med Ctr, Dept Gynecol, Kure, Japan

[14] Gunma Prefectural Canc Ctr, Dept Radiat Oncol, Gunma, Japan

[15] Saitama Canc Ctr, Dept Gynecol, Saitama, Japan

[16] Natl Canc Ctr, Dept Radiat Oncol, Tokyo, Japan

[17] Mitsui Mem Hosp, Dept Obstet & Gynecol, Tokyo, Japan

[18] Tokyo Metropolitan Bokutoh Hosp, Dept Obstet & Gynecol, Tokyo, Japan

[19] Univ Ryukyus, Grad Sch Med Sci, Dept Radiol, Nishihara, Okinawa, Japan

来源：

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | 2019年 / 24卷 / 05期

关键词：

Cervical cancer; Cisplatin; Concurrent chemoradiotherapy; Postoperative; Three-dimensional radiotherapy; CONFORMAL RADIATION-THERAPY; RADICAL HYSTERECTOMY; CONCURRENT CHEMOTHERAPY; ADJUVANT RADIOTHERAPY; PELVIC RADIOTHERAPY; RANDOMIZED-TRIAL; FOLLOW-UP; CARBOPLATIN; PACLITAXEL; CARCINOMA;

D O I：

10.1007/s10147-018-01380-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background The aim of this study was to evaluate the effects of treatment with both three-dimensional radiotherapy (3DRT) and weekly 40-mg/m(2) cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors. Methods We conducted a retrospective multi-institutional chart review of postoperative uterine cervical cancer patients with high-risk prognostic factors who had been treated with both 3DRT and weekly 40-mg/m(2) cisplatin from 2007 to 2012. Each participating hospital provided detailed information regarding patient characteristics, treatment outcomes, and treatment complications. Results The eligible 96 patients were analyzed. The median follow-up period was 61 months. The 3-year relapse-free survival, overall survival (OS), and locoregional relapse-free survival (LRFS) rates were 76%, 90%, and 88%, respectively. In multivariate analysis, the histological finding of either adenocarcinoma or adenosquamous carcinoma was a significant risk factor for both OS and LRFS. The percentage of patients with grade >= 3 acute hematologic toxicity, acute lower gastrointestinal toxicity (GIT), and late lower GIT were 45%, 19%, and 17%, respectively. Conclusions The outcomes of concurrent chemoradiotherapy (CCRT) using weekly 40-mg/m(2) cisplatin are similar to those in the previous studies that used several chemotherapy regimens. However, postoperative CCRT using 3DRT had a high level of late GIT.

引用

页码：575 / 582

页数：8

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