Bone Health and Associated Metabolic Complications in Neuromuscular Diseases

被引：29

作者：

Joyce, Nanette C. ^{[1
]}

Hache, Lauren P. ^{[2
]}

Clemens, Paula R. ^{[3
,4
]}

机构：

[1] Univ Calif Davis, Dept Rehabil Med, Sacramento, CA 95817 USA

[2] Childrens Natl Med Ctr, Ctr Genet Med, Washington, DC 20010 USA

[3] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15213 USA

[4] Dept Vet Affairs Med Ctr, Neurol Serv, Pittsburgh, PA 15240 USA

来源：

PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA | 2012年 / 23卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Neuromuscular disease; Bone density; Vitamin D; Glucocorticoids; Scoliosis; SPINAL MUSCULAR-ATROPHY; AMYOTROPHIC-LATERAL-SCLEROSIS; VITAMIN-D SUPPLEMENTATION; NECROSIS-FACTOR RECEPTOR; MINERAL DENSITY; NATURAL-HISTORY; PARATHYROID-HORMONE; GLUCOCORTICOID ACTION; OSTEOCLAST DIFFERENTIATION; VERTEBRAL COMPRESSION;

D O I：

10.1016/j.pmr.2012.08.005

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

This article reviews the recent literature regarding bone health as it relates to the patient living with neuromuscular disease (NMD). Studies defining the scope of bone-related disease in NMD are scant. The available evidence is discussed, focusing on abnormal calcium metabolism, increased fracture risk, and the prevalence of both scoliosis and hypovitaminosis D in Duchenne muscular dystrophy, amyotrophic lateral sclerosis, and spinal muscular atrophy. Future directions are discussed, including the urgent need for studies both to determine the nature and extent of poor bone health, and to evaluate the therapeutic effect of available osteoporosis treatments in patients with NMD.

引用

页码：773 / +

页数：28

共 174 条

[1] Bone loss in thyroid disease - Role of low TSH and high thyroid hormone [J].

Abe, Etsuko ;

Sun, Li ;

Mechanick, Jeffrey ;

Iqbal, Jameel ;

Yamoah, Kosj ;

Baliram, Ramkumarie ;

Arabi, Ario ;

Moonga, Baljit S. ;

Davies, Terry E. ;

Zaidi, Mone .

SKELETAL BIOLOGY AND MEDICINE, PT A: ASPECTS OF BONE MORPHOGENESIS AND REMODELING, 2007, 1116 :383-391

[2] Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe [J].

Abrahamsen, B. ;

Masud, T. ;

Avenell, A. ;

Anderson, F. ;

Meyer, H. E. ;

Cooper, C. ;

Smith, H. ;

LaCroix, A. Z. ;

Torgerson, D. ;

Johansen, A. ;

Jackson, R. ;

Rejnmark, L. ;

Wactawski-Wende, J. ;

Brixen, K. ;

Mosekilde, L. ;

Robbins, J. A. ;

Francis, R. M. .

BMJ-BRITISH MEDICAL JOURNAL, 2010, 340 :139

[3]

Adler C.P., 2000, Bone Diseases, V1st, P1, DOI DOI 10.1007/978-3-662-04088-1_1

[4] Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial [J].

Aggarwal, Swati P. ;

Zinman, Lorne ;

Simpson, Elizabeth ;

McKinley, Jane ;

Jackson, Katherine E. ;

Pinto, Hanika ;

Kaufman, Petra ;

Conwit, Robin A. ;

Schoenfeld, David ;

Shefner, Jeremy ;

Cudkowicz, Merit .

LANCET NEUROLOGY, 2010, 9 (05) :481-488

[5] Leptin [J].

Ahima, RS ;

Flier, JS .

ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437

[6]

Alton J, 2011, PREVALENCE INADEQUAT

[7] Androgen supplementation in eugonadal men with osteoporosis - Effects of 6 months of treatment on bone mineral density and cardiovascular risk factors [J].

Anderson, FH ;

Francis, RM ;

Faulkner, K .

BONE, 1996, 18 (02) :171-177

[8] Decreased bone density in ambulatory patients with Duchenne muscular dystrophy [J].

Aparicio, LF ;

Jurkovic, M ;

DeLullo, J .

JOURNAL OF PEDIATRIC ORTHOPAEDICS, 2002, 22 (02) :179-181

[9] Acquisition of optimal bane mass in childhood and adolescence [J].

Bachrach, LK .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2001, 12 (01) :22-28

[10] Taking steps towards reducing osteoporosis in Duchenne Muscular Dystrophy [J].

Bachrrach, LK .

NEUROMUSCULAR DISORDERS, 2005, 15 (01) :86-87

← 1 2 3 4 5 6 7 8 9 10 →