Pre-XDR & XDR in MDR and Ofloxacin and Kanamycin resistance in non-MDR Mycobacterium tuberculosis isolates

被引：21

作者：

Jain, Amita ^{[1
]}

Dixit, Pratima ^{[1
]}

Prasad, Rajendra ^{[2
]}

机构：

[1] CSM Med Univ, Dept Microbiol, Lucknow 226003, Uttar Pradesh, India

[2] CSM Med Univ, Dept Pulm Med, Lucknow 226003, Uttar Pradesh, India

来源：

TUBERCULOSIS | 2012年 / 92卷 / 05期

关键词：

M; tuberculosis; Drug resistance; MDR-TB; XDR-TB; Pre-; 2ND-LINE DRUG-RESISTANCE; MULTIDRUG; SURVEILLANCE; PREVALENCE; PATTERNS; STATE;

D O I：

10.1016/j.tube.2012.05.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Resistance to second line anti tubercular drugs is a cause of serious concern. The present study reports the prevalence of Ofloxacin (OFX) and Kanamycin (KM) resistance in Mycobacterium tuberculosis isolates from cases of pulmonary tuberculosis, who received anti tubercular treatment for >4 weeks in past. Of total 438 enrolled patients, 361 were culture positive for M. tuberculosis, of which, 95 (26.3%) were OFX resistant & 49 (13.5%) were KM resistant. Total 130 isolates were Multidrug resistant, of which, 55 (42.3%) were resistant to either OFX or KM (Pre-XDR) & 11 (8.5%) were resistant to both KM & OFX (XDR). Resistance to quinolones & aminoglycosides should be routinely assessed in areas endemic for tuberculosis. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：404 / 406

页数：3

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