Palladium(II) Catalyzed Suzuki/Sonogashira Cross-Coupling Reactions of Sulfonates: An Efficient Approach to C2-Functionalized Pyrimidines and Pyridines

被引：42

作者：

Quan, Zheng-Jun ^{[1
]}

Jing, Fu-Qiang ^{[1
]}

Zhang, Zhang ^{[1
]}

Da, Yu-Xia ^{[1
]}

Wang, Xi-Cun ^{[1
]}

机构：

[1] Northwest Normal Univ, Lab Ecoenvironm Related Polymer Mat, Coll Chem & Chem Engn, Minist Educ,Gansu Key Lab Polymer Mat, Lanzhou 730070, Gansu, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 31期

关键词：

Synthetic methods; C-C coupling; Cross-coupling; Nitrogen heterocycles; Palladium; Alkynes; CALCIUM-CHANNEL BLOCKERS; SUZUKI-MIYAURA; ARYLBORONIC ACIDS; CARBON-CARBON; BIGINELLI 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE; ARYL IMIDAZOLYLSULFONATES; SONOGASHIRA REACTIONS; PHASE SYNTHESIS; BORONIC ACIDS; SOLID-PHASE;

D O I：

10.1002/ejoc.201300592

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrimidin-2-yl sulfonates, as a reaction partner, can be easily prepared from inexpensive commercial materials and are efficiently cross-coupled with arylboronic acids and terminal alkynes by using Pd(OAc)(2)-catalyzed Suzuki and Sonogashira reactions. A wide array of C2-functionalized pyrimidines have been prepared in good to excellent yields. 2-Arylpyridines and 2-(oct-1-ynyl)pyridine were also synthesized.

引用

页码：7175 / 7183

页数：9

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