An improved process for the synthesis of DMTMM-based coupling reagents

被引：54
|
作者：
Raw, Steven A. [1 ]
机构：
[1] AstraZeneca, Proc Res & Dev, Macclesfield SK11 8AA, Cheshire, England
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 08期
关键词：
CARBOXYLIC-ACIDS; CONDENSING AGENT; ACTIVATION;
D O I：
10.1016/j.tetlet.2008.12.047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, robust and high-yielding process for the preparation of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium tetrafluoroborate (DMTMM BF4) and hexafluorophosphate (DMTMM PF6) has been developed, which avoids the use of expensive or unusual reagents. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：946 / 948
页数：3
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