Metabolic programming of tumor associated macrophages in the context of cancer treatment

被引：20

作者：

Crezee, Thomas ^{[1
,2
]}

Rabold, Katrin ^{[3
,4
,5
]}

de Jong, Lisanne ^{[3
]}

Jaeger, Martin ^{[3
,5
,6
]}

Netea-Maier, Romana T. ^{[6
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, Nijmegen, Netherlands

[2] Radboud Inst Mol Life Sci, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Radiat Oncol, Radiotherapy & OncoImmunol Lab, Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Nijmegen Med Ctr, Radboud Inst Mol Life Sci RIMLS, Geert Grootepl Zuid 28, NL-6525 GA Nijmegen, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Div Endocrinol, Geert Grootepl Zuid 8, NL-6525 GA Nijmegen, Netherlands

来源：

ANNALS OF TRANSLATIONAL MEDICINE | 2020年 / 8卷 / 16期

关键词：

Immunotherapy; metabolism; thyroid cancer; tumor associated macrophages; tumor microenvironment (TME); PANCREATIC DUCTAL ADENOCARCINOMA; INFILTRATING MACROPHAGES; APOPTOTIC CELLS; DRUG-RESISTANCE; M2; MACROPHAGES; MYELOID CELLS; M-CSF; POLARIZATION; ACID; GROWTH;

D O I：

10.21037/atm-20-1114

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor associated macrophages (TAMs) are important components of the tumor microenvironment (TME). They are characterized by a remarkable functional plasticity, thereby mostly promoting cancer progression. Changes in immune cell metabolism are paramount for this functional adaptation. Here, we review the functional consequences of the metabolic programming of TAMs and the influence of local and systemic targeted therapies on the metabolic characteristics of the TME that shape the functional phenotype of the TAMs. Understanding these metabolic changes within the context of the cross-talk between the different components of the TME including the TAMs and the tumor cells is an essential step that can pave the way towards identifications of ways to improve responses to different treatments, to overcome resistance to treatments, tumor progression and reduce treatment-specific toxicity.

引用

页数：17

共 147 条

[1] Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma [J].

Ao, Jian-Yang ;

Zhu, Xiao-Dong ;

Chai, Zong-Tao ;

Cai, Hao ;

Zhang, Yuan-Yuan ;

Zhang, Ke-Zhi ;

Kong, Ling-Qun ;

Zhang, Ning ;

Ye, Bo-Gen ;

Ma, De-Ning ;

Sun, Hui-Chuan .

MOLECULAR CANCER THERAPEUTICS, 2017, 16 (08) :1544-1554

[2] Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages [J].

Arts, Rob J. W. ;

Plantinga, Theo S. ;

Tuit, Sander ;

Ulas, Thomas ;

Heinhuis, Bas ;

Tesselaar, Marika ;

Sloot, Yvette ;

Adema, Gosse J. ;

Joosten, Leo A. B. ;

Smit, Johannes W. A. ;

Netea, Mihai G. ;

Schultze, Joachim L. ;

Netea-Maier, Romana T. .

ONCOIMMUNOLOGY, 2016, 5 (12)

[3] Investigation into the role of tumor-associated macrophages in the antitumor activity of Doxil [J].

Banciu, Manuela ;

Schiffelers, Raymond M. ;

Storm, Gert .

PHARMACEUTICAL RESEARCH, 2008, 25 (08) :1948-1955

[4] Analysis of the role of chemokines in angiogenesis [J].

Bernardini, G ;

Ribatti, D ;

Spinetti, G ;

Morbidelli, L ;

Ziche, M ;

Santoni, A ;

Capogrossi, MC ;

Napolitano, M .

JOURNAL OF IMMUNOLOGICAL METHODS, 2003, 273 (1-2) :83-101

[5] Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progression [J].

Bianchini, Francesca ;

Massi, Daniela ;

Marconi, Chiara ;

Franchi, Alessandro ;

Baroni, Gianna ;

Santucci, Marco ;

Antonella, Mannini ;

Mugnai, Gabriele ;

Calorini, Lido .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2007, 83 (04) :320-328

[6] Tumor-associated macrophages: functional diversity, clinical significance, and open questions [J].

Biswas, Subhra K. ;

Allavena, Paola ;

Mantovani, Alberto .

SEMINARS IN IMMUNOPATHOLOGY, 2013, 35 (05) :585-600

[7] Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm [J].

Biswas, Subhra K. ;

Mantovani, Alberto .

NATURE IMMUNOLOGY, 2010, 11 (10) :889-896

[8] Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis [J].

Bonapace, Laura ;

Coissieux, Marie-May ;

Wyckoff, Jeffrey ;

Mertz, Kirsten D. ;

Varga, Zsuzsanna ;

Junt, Tobias ;

Bentires-Alj, Mohamed .

NATURE, 2014, 515 (7525) :130-133

[9] Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death [J].

Casares, N ;

Pequignot, MO ;

Tesniere, A ;

Ghiringhelli, F ;

Roux, S ;

Chaput, N ;

Schmitt, E ;

Hamai, A ;

Hervas-Stubbs, S ;

Obeid, M ;

Coutant, F ;

Métivier, D ;

Pichard, E ;

Aucouturier, P ;

Pierron, G ;

Garrido, C ;

Zitvogel, L ;

Kroemer, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (12) :1691-1701

[10] Targeting macrophages: therapeutic approaches in cancer [J].

Cassetta, Luca ;

Pollard, Jeffrey W. .

NATURE REVIEWS DRUG DISCOVERY, 2018, 17 (12) :887-904

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