Neuroprotection targeting ischemic penumbra and beyond for the treatment of ischemic stroke
被引:51
作者:
Liu, Ran
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Texas, Hlth Sci Ctr, Dept Pharmacol, Ft Worth, TX 76107 USA
Univ N Texas, Hlth Sci Ctr, Dept Neurosci, Ft Worth, TX 76107 USAUniv N Texas, Hlth Sci Ctr, Dept Pharmacol, Ft Worth, TX 76107 USA
Liu, Ran
[1
,2
]
Yuan, Hui
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R ChinaUniv N Texas, Hlth Sci Ctr, Dept Pharmacol, Ft Worth, TX 76107 USA
Yuan, Hui
[3
]
Yuan, Fang
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R ChinaUniv N Texas, Hlth Sci Ctr, Dept Pharmacol, Ft Worth, TX 76107 USA
Yuan, Fang
[3
]
Yang, Shao-Hua
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Texas, Hlth Sci Ctr, Dept Pharmacol, Ft Worth, TX 76107 USA
Univ N Texas, Hlth Sci Ctr, Dept Neurosci, Ft Worth, TX 76107 USAUniv N Texas, Hlth Sci Ctr, Dept Pharmacol, Ft Worth, TX 76107 USA
Yang, Shao-Hua
[1
,2
]
机构:
[1] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol, Ft Worth, TX 76107 USA
[2] Univ N Texas, Hlth Sci Ctr, Dept Neurosci, Ft Worth, TX 76107 USA
[3] Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China
Neuroprotection to attenuate or block the ischemic cascade and salvage neuronal damage has been extensively explored for the treatment of ischemic stroke. In the last two decades, neuroprotective strategy has been evolving from targeting a signal pathway in neurons to protecting all neurovascular components and improving cell-cell and cell-extracellular matrix interaction that ultimately benefits the brain recovery after ischemic stroke. The progression from potentially reversible to irreversible injury in the ischemic penumbra has provided the opportunity to develop therapies to attenuate the ischemic stroke damage. Thus, the ischemic penumbra has been the main target for the current neuroprotective intervention. However, despite our increasing knowledge of the physiologic, mechanistic, and imaging characterizations of the ischemic penumbra, no effective neuroprotective therapy has been found so far for the treatment of ischemic stroke. The current acute neuroprotective approach focusing on the damaging mechanisms at the ischemic penumbra is greatly limited by the rapid evolution of the deleterious cascades in the ischemic penumbra. Neuroprotective intervention attempts to promote endogenous repairing in the transition zone of the penumbra for the therapeutic purposes may overcome the unrealistic therapeutic windows under the current neuroprotective strategy. In addition, increasing evidence has indicated ischemic stroke could induce long-lasing cellular and hemodynamic changes beyond the ischemic territory. It is unclear whether and how the global responses induced by the ischemic cascade contribute to the progression of cognitive impairment after ischemic stroke. The prolonged pathophysiological cascades induced by ischemic stroke beyond the ischemic penumbra might provide novel therapeutic opportunities for the neuroprotective intervention, which could prevent or slow down the progression of vascular dementia after ischemic stroke.
机构:
Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South KoreaUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Bang, O. Y.
;
Saver, J. L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Saver, J. L.
;
Buck, B. H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alberta, Dept Med, Div Neurol, Edmonton, AB T6G 2M7, CanadaUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Buck, B. H.
;
Alger, J. R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Alger, J. R.
;
Starkman, S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Stroke Ctr, Dept Emergency Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Starkman, S.
;
Ovbiagele, B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Ovbiagele, B.
;
Kim, D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Kim, D.
;
Jahan, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Radiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Jahan, R.
;
Duckwiler, G. R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Radiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Duckwiler, G. R.
;
Yoon, S. R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Radiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Yoon, S. R.
;
Vinuela, F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Radiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Vinuela, F.
;
Liebeskind, D. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
机构:
Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South KoreaUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Bang, O. Y.
;
Saver, J. L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Saver, J. L.
;
Buck, B. H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alberta, Dept Med, Div Neurol, Edmonton, AB T6G 2M7, CanadaUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Buck, B. H.
;
Alger, J. R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Alger, J. R.
;
Starkman, S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Stroke Ctr, Dept Emergency Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Starkman, S.
;
Ovbiagele, B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Ovbiagele, B.
;
Kim, D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Kim, D.
;
Jahan, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Radiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Jahan, R.
;
Duckwiler, G. R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Radiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Duckwiler, G. R.
;
Yoon, S. R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Radiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Yoon, S. R.
;
Vinuela, F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Radiol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA
Vinuela, F.
;
Liebeskind, D. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Stroke Ctr, Dept Neurol, Los Angeles, CA 90095 USA