Multiple centrosomes: together they stand, divided they fall

被引：51

作者：

Gergely, Fanni ^{[2
]}

Basto, Renata ^{[1
]}

机构：

[1] Inst Curie, CNRS, UMR 144, Paris 05, France

[2] Univ Cambridge, Dept Oncol, Cambridge Res Inst, Cancer Res UK,Li Ka Shing Ctr, Cambridge CB2 0RE, England

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 17期

关键词：

centrosomes; mitosis; actin; adhesion; cancer; cell cycle;

D O I：

10.1101/gad.1715208

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells with extra centrosomes rely entirely on centrosome clustering mechanisms to assemble a bipolar spindle and to divide in a bipolar fashion. To identify the pathways involved in suppression of multipolarity, Kwon, Godinho, and colleagues ( pp. 2189-2203) have set up a genome-wide screen in Drosophila S2 cells. Surprisingly, they found that efficient clustering requires a large number of proteins associated with a variety of cellular functions.

引用

页码：2291 / 2296

页数：6

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