Systemic Atopy and Immunoglobulin Deficiency in Turkish Patients with Vernal Keratoconjunctivitis

被引：11

作者：

Bozkurt, Banu ^{[1
]}

Artac, Hasibe ^{[2
]}

Arslan, Nasha ^{[3
]}

Gokturk, Bahar ^{[4
]}

Bozkurt, Mete Kaan ^{[5
]}

Reisli, Ismail ^{[4
]}

Irkec, Murat ^{[6
]}

机构：

[1] Selcuk Univ, Fac Med, Dept Ophthalmol, Konya, Turkey

[2] Selcuk Univ, Fac Med, Dept Pediat Allergy & Immunol, Konya, Turkey

[3] Ipekyolu State Hosp, Van, Turkey

[4] Necmettin Erbakan Univ, Meram Med Fac, Dept Pediat Allergy & Immunol, Konya, Turkey

[5] Selcuk Univ, Selcuklu Med Fac, Dept Ophthalmol, Konya, Turkey

[6] Hacettepe Univ, Fac Med, Dept Ophthalmol, TR-06100 Ankara, Turkey

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2013年 / 21卷 / 01期

关键词：

Allergic sensitization; Immunoglobulin deficiency; Serum specific IgE level; Skin prick tests; Vernal keratoconjunctivitis; EOSINOPHIL CATIONIC PROTEIN; IGA DEFICIENCY; CASE SERIES; EXPRESSION; CHILDREN; ALLERGEN; EYE; IMMUNODEFICIENCIES; DERMATITIS; CHILDHOOD;

D O I：

10.3109/09273948.2012.723110

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To determine the prevalence of systemic atopy and immunoglobulin (Ig) deficiencies in vernal keratoconjunctivitis (VKC). Methods: Sixty-seven VKC subjects (79.1% boys) with a mean age of 11.3 +/- 4.3 years were included. Serum Ig levels and specific IgE levels were measured using the nephelometric method and reversed enzyme immunoassay with sandwich ELISA technique, respectively. The patients underwent epidermal skin tests with commercial extracts. Results: Family history of atopy and associated systemic allergies were detected in 32.8 and 40.3% of the subjects, respectively. Blood eosinophilia, elevated total, and specific IgE and positive skin tests were detected in 33.8, 42.2, 50, and 35% of the subjects, respectively. Out of 62 subjects, low levels of IgA, IgG, IgM, and IgG3 were detected in 12.9, 8, 6.5, and 1.6% of the patients, respectively. Conclusion: IgE-mediated mechanisms are involved in approximately 40% of VKC patients. A new finding was the higher incidence of Ig deficiency.

引用

页码：21 / 26

页数：6

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