Palladium-Catalyzed Carbonylative Heck Reaction of Aryl Bromides with Vinyl Ethers to 3-Alkoxy Alkenones and Pyrazoles

被引：56
|
作者：
Schranck, Johannes [1 ]
Wu, Xiao-Feng [1 ]
Neumann, Helfried [1 ]
Beller, Matthias [1 ]
机构：
[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 16期
关键词：
aryl bromides; carbonylation; palladium; pyrazoles; vinyl ethers; CROSS-COUPLING REACTIONS; HETEROARYL BROMIDES; SONOGASHIRA REACTIONS; ORGANIC HALIDES; ARYLBORONIC ACIDS; TERMINAL ALKYNES; KETONE SYNTHESIS; SUZUKI REACTION; BIARYL KETONES; BORONIC ACIDS;
D O I：
10.1002/chem.201103643
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three COming together: The first carbonylative Heck coupling reaction of aryl bromides and vinyl ethers leading to 1-aryl-3-alkoxy-2-propen-1-ones has been established (see scheme). Based on this coupling methodology, a novel one-pot synthesis of aryl-substituted pyrazoles was also realized. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4827 / 4831
页数：5
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