Soluble urokinase-type plasminogen activator receptor (suPAR) is elevated in caregivers of patients with parkinsonism

被引:2
作者
Joyce, Jessica [1 ]
Cabanas, Noel [1 ]
Pisharody, Rohan [1 ]
Ouyang, Bichun [2 ]
Patel, Roshni [1 ]
Reiser, Jochen [3 ]
Hall, Deborah A. [1 ]
Witek, Natalie [1 ]
机构
[1] Rush Univ, Med Ctr, Dept Neurol Sci, 1725 West Harrison St,Suite 755, Chicago, IL 60612 USA
[2] Rush Univ, Dept Biostat, Chicago, IL 60612 USA
[3] Rush Med Coll, Dept Internal Med, Chicago, IL 60612 USA
关键词
Soluble urokinase-type plasminogen activator receptor (suPAR); Caregive; Parkinson's disease; Parkinsonism; Caretaker; CHRONIC STRESS; DISEASE; LIFE;
D O I
10.1016/j.parkreldis.2022.06.019
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Caregivers are integral to the care of those with neurological disorders such as Parkinson's Disease (PD), but are often burdened by stress, anxiety, and depression. Previous research has suggested that the foundation of such stress is low-grade systemic inflammation, as evidenced by increased interleukin 6 (IL-6) and C-reactive protein (CRP) levels. Soluble urokinase-type plasminogen activator receptor (suPAR) is a kidney disease risk factor and marker of chronic inflammation that integrates psycho-social stress and organ dysfunction. Caregivers of PD experience an extraordinary amount of stress and suPAR's role as prognostic marker has not yet been assessed in caregivers of PD. The aim of this study was to determine the relationship between suPAR levels and PD caregiver burden. Healthy volunteers who accompanied patients with parkinsonism (n = 35) donated blood samples, and complete blood counts (CBC), CRP, and suPAR levels were measured. Participants were then interviewed by telephone and stratified into primary and non-primary caregiver groups. Their caregiver burden was quantified through the Zarit Caregiver Burden Short Form (ZBI-12). The resultant data demonstrated higher plasma levels of suPAR and ZBI-12 scores for the primary caregiver group relative to the non-primary caregiver group (suPAR level: 3.73 vs. 2.72 ng/mL, p = 0.01; ZBI-12: 18.57 vs. 5.4, p < 0.0001; Table). The data also revealed a moderate positive correlation between suPAR and ZBI-12 scores. These findings not only demonstrate a correlation between elevated suPAR and caregiving burden in PD, but also further support and raise awareness for the overall psychosocial burden and stress experienced by those caregivers.
引用
收藏
页码:39 / 42
页数:4
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